1023298-74-9

Basic information

• Product Name: C₁₉H₂₂BrFN₄O₃S
• Synonyms: C₁₉H₂₂BrFN₄O₃S
• CAS NO: 1023298-74-9
• Molecular Weight: 485.377
• Mol File: 1023298-74-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₂BrFN₄O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₂BrFN₄O₃S(1023298-74-9)
• EPA Substance Registry System: C₁₉H₂₂BrFN₄O₃S(1023298-74-9)

Safety Data

• Hazardous Substances Data: 1023298-74-9(Hazardous Substances Data)

Upstream product

• 5198-88-9 2-bromothiazole-4-carboxylic Acid 
• 1023298-69-2 t-butyl 4-(2-amino-4-fluorophenyl)piperazine-1-carboxylate 

Downstream Products

• 1023298-83-0 C₂₈H₃₀FN₅O₅S 
• 1023296-26-5 C₂₃H₂₂FN₅O₃S 
• 1023298-84-1 C₂₉H₃₂FN₅O₄S 

Relevant articles and documents

Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

Drug design efforts in the emerging 2-aminothiazole-4-carboxamide class of CHK1 inhibitors have uncovered specific combinations of key substructures within the molecule; resulting in significant improvements in cell-based activity while retaining a greater than one hundred-fold selectivity against CDK2. The X-ray crystal structure of a complex between compound 39 and the CHK1 protein detailing a 'U-shaped' topology and key interactions with the protein surface at the ATP site is also reported.