102389-19-5

Basic information

• Product Name: 2-(2-isopropylphenyl)imino-5,5-dimethyl-1,3-thiazine
• Synonyms: 2-(2-isopropylphenyl)imino-5,5-dimethyl-1,3-thiazine
• CAS NO: 102389-19-5
• Molecular Weight: 262.419
• Mol File: 102389-19-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-isopropylphenyl)imino-5,5-dimethyl-1,3-thiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-isopropylphenyl)imino-5,5-dimethyl-1,3-thiazine(102389-19-5)
• EPA Substance Registry System: 2-(2-isopropylphenyl)imino-5,5-dimethyl-1,3-thiazine(102389-19-5)

Safety Data

• Hazardous Substances Data: 102389-19-5(Hazardous Substances Data)

Upstream product

• 643-28-7 2-isopropylaniline 
• 36176-31-5 1-isopropyl-2-isothiocyanatobenzene 
• 330479-76-0 N-(2-isopropylphenyl)-N'-(3-hydroxy-2,2-dimethyl)propylthiourea 

Relevant articles and documents

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds

Structure-activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.

MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE

A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: wherein R1 is optionally substituted heterocyclic group or the like; R2 and R2 each is independently hydrogen or the like; m is an