1024-64-2

Basic information

• Product Name: (2-methylphenyl)(2,4,6-trimethylphenyl)methanone
• Synonyms: Benzophenone, 2,2',4,6-tetramethyl-; Methanone, (2-methylphenyl)(2,4,6-trimethylphenyl)-
• CAS NO: 1024-64-2
• Molecular Formula: C₁₇H₁₈O
• Molecular Weight: 238.3242
• Mol File: 1024-64-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 313.2°C at 760 mmHg
• Flash Point: 129°C
• Density: 1.024g/cm³
• Vapor Pressure: 0.000503mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: (2-methylphenyl)(2,4,6-trimethylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenyl)(2,4,6-trimethylphenyl)methanone(1024-64-2)
• EPA Substance Registry System: (2-methylphenyl)(2,4,6-trimethylphenyl)methanone(1024-64-2)

Safety Data

• Hazardous Substances Data: 1024-64-2(Hazardous Substances Data)

Usage

Description

(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is a ketone with two aromatic rings attached, formed by the combination of one molecule of 2-methylphenyl and one molecule of 2,4,6-trimethylphenyl.

Uses

Used in Organic Chemistry:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is used as a building block for the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity.
Used in Production of Other Organic Compounds:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is used as a reagent in the production of other organic compounds, contributing to the synthesis of a wide range of chemical products.
Used in Drug Discovery Research:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is studied for its potential biological and pharmacological activities, making it a target for drug discovery research and development.

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 932-31-0 ortho-tolylmagnesium bromide 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 615-37-2 ortho-methylphenyl iodide 
• 201230-82-2 carbon monoxide 
• 5980-97-2 mesitylboronic acid 
• 4028-63-1 iodomesitylene 
• 16419-60-6 2-Methylphenylboronic acid 
• 487-68-3 mesytaldehyde 
• 68971-87-9 (2-tolyl)tributyltin 
• 118-90-1 ortho-methylbenzoic acid 
• 13630-19-8 2-methylbenzotrifluoride 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 21945-77-7 2,4,6,2'-Tetramethyl-benzhydrol 
• 101787-43-3 methyl-(2,4,6,2'-tetramethyl-benzhydryl)-ether 
• 143617-11-2 Mesityl-o-tolyl-methanol 

Relevant articles and documents

Synthesis of Diverse Aromatic Ketones through C?F Cleavage of Trifluoromethyl Group

An efficient synthetic method of aromatic ketones through C?F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled mult

Sterically Hindered Ketones via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation

Herein, we report a new protocol for the synthesis of sterically hindered ketones that proceeds via palladium-catalyzed Suzuki-Miyaura cross-coupling of unconventional amide electrophiles by selective N-C(O) activation. Mechanistic studies demonstrate that steric bulk on the amide has a major impact, which is opposite to the traditional Suzuki-Miyaura cross-coupling of sterically hindered aryl halides. Structural and computational studies provide insight into ground-state distortion of sterically hindered amides and show that ortho-substitution alleviates the N-C(O) bond twist.

Selective synthetic routes to sterically hindered unsymmetrical diaryl ketones via arylstannanes

Bulky arylstannanes and bulky aroyl chlorides are good reaction partners for the synthesis of two-, three-, and even four-ortho-substituted benzophenones, in good to excellent isolated yields (47-91%). Three simple and direct routes, with differential advantages, are proposed: (i) a catalyst-free protocol, in o-dichlorobenzene (ODCB) at 180 °C; (ii) a room temperature protocol, using AlCl3 (0.5 equiv), in dichloromethane (DCM); and (iii) a solvent-free, indium-promoted procedure. A radical mechanism is proposed for the indium-mediated reactions.2011 American Chemical Society.