102410-49-1

Basic information

• Product Name: Z-D-Abu-Pro-OBu^t
• Synonyms: Z-D-Abu-Pro-OBu^t
• CAS NO: 102410-49-1
• Molecular Weight: 390.48
• Mol File: 102410-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Z-D-Abu-Pro-OBu^t(CAS DataBase Reference)
• NIST Chemistry Reference: Z-D-Abu-Pro-OBu^t(102410-49-1)
• EPA Substance Registry System: Z-D-Abu-Pro-OBu^t(102410-49-1)

Safety Data

• Hazardous Substances Data: 102410-49-1(Hazardous Substances Data)

Upstream product

• 2900-20-1 (2R)-2-[(phenylmethoxy)carbonyl]aminobutanoic acid 
• 2812-46-6 proline tert-butyl ester 

Downstream Products

• 102410-51-5 H-D-Abu-Pro-OBu^t*TosOH 
• 2900-22-3 Z-D-Abu-Pro 
• 117194-52-2 cyclo-Z-Thr-D-Abu-Pro-MePhe-D/L-Phg- 
• 102410-64-0 (4R,5R)-3-(Benzyloxy)-N-(5-methyl-2-oxo-1,3-oxazolidin-4-yl)picolinsaeureamid 
• 102410-52-6 Pic(3-OBzl)-Thr-D-Abu-Pro-OBu^t 
• 102410-58-2 Pic(3-OBzl)-Thr(Ddz-Phg)-D-Abu-Pro-OBu^t 
• 102410-44-6 3-Benzyloxy-pyridine-2-carboxylic acid ((3S,6S,15S,16R,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl)-amide 
• 102410-55-9 Pic(3-OBzl)-Thr(Fmoc-Phg-)-D-Abu-Pro-OBu^t 
• 102410-60-6 Pic(3-OBzl)-Thr(H-Phg)-D-Abu-Pro-OBu^t*TFA 
• 102410-62-8 Pic(3-OBzl)-Thr(Boc-MePhe-4Kps-Phg-)-D-Abu-Pro-OBu^t 
• 102410-63-9 Pic(3-OBzl)-Thr(H-MePhe-4Kps-Phg-)-D-Abu-Pro-OH*2HCl 
• 102410-59-3 Pic(3-OBzl)-Thr(H-Phg)-D-Abu-Pro-OBu^t 

Relevant articles and documents

THE SYNTHESIS OF A Nγ-PHTHALYL-Nα-METHYL-α,γ-DIAMINOBUTYRYL CONGENER OF VIRGINIAMYCIN S1

A synthesis of (A2bu=α,γ-diaminobutyric acid) is reported using the very efficient coupling agent BOP-Cl (N,N'-bis(3-oxo-2-oxazolidinyl)phosphinic chloride) for imino acid peptide bond formation.The total yield is 11percent for the 5 coupling steps and one lactonization.The final step was a cyclization between residues 5 and 6, after (I) first t-Boc acidic deprotection with 85percent HCOOH of the linear precursor Z-Thr(Nα-Boc-Phg-O-)-D-Abu-Pro-MePhe-MeA2bu(γPht)-OBut followed by (ii) acidic saponification (Tfa) of the t-Bu ester.This sequence was found to be prerequisite, in view of the extreme lability of the 4-5 peptide bond under acidic conditions.