102423-74-5

Basic information

• Product Name: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-methoxyphenyl)-
• CAS NO: 102423-74-5
• Molecular Formula: C14H12N4OS
• Molecular Weight: 284.341
• Mol File: 102423-74-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-methoxyphenyl)-(102423-74-5)
• EPA Substance Registry System: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-methoxyphenyl)-(102423-74-5)

Safety Data

• Hazardous Substances Data: 102423-74-5(Hazardous Substances Data)

Usage

Chemical compound

4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-methoxyphenyl)-

Class

Thiopyrans

Description

Heterocyclic compound containing a five-membered sulfur ring fused to a six-membered pyran ring

Functional groups present

Two cyano groups, two amino groups, and a methoxyphenyl group

Applications

Used in organic synthesis and medicinal chemistry as a building block for the synthesis of biologically active compounds

Potential applications

Development of pharmaceuticals and agrochemicals due to diverse reactivity and structural features

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 39145-31-8 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 106763-17-1 4-methoxybenzylidenecyanothioacetamide 
• 107-10-8 propylamine 
• 75-15-0 carbon disulfide 

Downstream Products

• 299464-98-5 3,6-diamino-5-cyano-4-(4-methoxyphenyl)-thieno[2,3-b]pyridine-2-carboxamide 
• 110691-01-5 6-amino-4-(4-methoxyphenyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 110691-01-5 2-amino-4-(4-methoxyphenyl)-6-mercaptopyridine-3,5-dicarbonitrile 
• 14482-11-2 p-methoxycinnamonitrile 

Relevant articles and documents

Multicomponent Synthesis of 4-Alkyl(Aryl, Hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)- 3,6-diamino-5-cyanothieno[2,3-b]pyridines

The condensation of malononitrile with hydrogen sulfide and aldehydes in the presence of triethylamine in ethanol at room temperature afforded 4-alkyl(aryl, hetaryl)-2,6-diamino-3,5-dicyano-4H-thiopyrans. Treatment of the latter in situ with alkali in DMF, followed by addition of an alkylating agent, led to the formation of 4-alkyl(aryl, hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)-3,6-diamino-5-cyanothieno[2,3-b]- pyridines.

ACETYL-COA CARBOXYLASE MODULATORS

Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the control of fungal pathogens in plants.

Nitriles in Heterocyclic Synthesis: Novel Synthesis of 4H-Thiopyran and of 2-Hydroxy-6-pyridine Thione Derivatives

Reaction of arylmethylenemalononitrile 2a-c with cyanothioacetamide 1 afforded 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles 5a-c on refluxing in ethanolic aqueous triethylamine, rearranged to yield the 4-aryl-1,2-dihydro-6-hydroxy-2-thioxo-3,5-pyridine dicarbonitriles 8a-c.The same compounds could be obtained on treatment of 2a-c with 1 in ethanolic aqueous triethylamine or on reacting 1 with 2d-f.The 13C NMR data of the products are reported and interpreted. - Keywords: Cyanothioacetamide, 2-Aminothiopyranes, Pyridine Thiones, 13C NMR Spectra