10245-81-5

Basic information

• Product Name: pentabromopseudilin
• Synonyms: pentabromopseudilin;2-(3,5-Dibromo-2-hydroxyphenyl)-3,4,5-tribromo-1H-pyrrole;2,3,4-Tribromo-5-(2-hydroxy-3,5-dibromophenyl)-1H-pyrrole;2,4-Dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol
• CAS NO: 10245-81-5
• Molecular Formula: C₁₀H₄Br₅NO
• Molecular Weight: 553.66
• Mol File: 10245-81-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 464.2°C at 760 mmHg
• Flash Point: 234.5°C
• Appearance: /
• Density: 2.606g/cm³
• Vapor Pressure: 3.07E-09mmHg at 25°C
• Refractive Index: 1.739
• CAS DataBase Reference: pentabromopseudilin(CAS DataBase Reference)
• NIST Chemistry Reference: pentabromopseudilin(10245-81-5)
• EPA Substance Registry System: pentabromopseudilin(10245-81-5)

Safety Data

• Hazardous Substances Data: 10245-81-5(Hazardous Substances Data)

Usage

Description

Pentabromopseudilin is a metabolite derived from Chromobacterium, a bacterium found in a seawater sample from the North Pacific Gyre. It exhibits significant antibiotic properties and is known to play a role in autoinhibition within the Chromobacterium itself.

Uses

Used in Pharmaceutical Industry:
Pentabromopseudilin is used as an antibiotic agent for its antibiotic action against various types of bacteria. The compound has demonstrated the ability to inhibit bacterial growth, making it a potential candidate for the development of new antibiotics to combat bacterial infections.
Used in Research and Development:
Pentabromopseudilin is also used as a research tool to study the mechanisms of autoinhibition in Chromobacterium and other similar bacteria. Understanding these mechanisms can provide insights into bacterial behavior and contribute to the development of targeted therapies and treatments for bacterial infections.

InChI:InChI=1/C10H4Br5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H

Upstream product

• 10245-83-7 3,4,5-Tribrom-2-(3',5'-dibrom-2'-methoxyphenyl)-1H-pyrrol 
• 42041-50-9 2-(2-hydroxyphenyl)-1H-pyrrole 
• 74303-03-0 2-(2-benzyloxyphenyl)-1H-pyrrole 
• 856438-60-3 4-(2-(benzyloxy)phenyl)-4-oxobutanal 
• 856438-59-0 1-(2-benzyloxy-phenyl)-pent-4-en-1-one 
• 856438-58-9 1-(2-benzyloxy-phenyl)-pent-4-en-1-ol 
• 856438-50-1 2-(2-benzyloxy-phenyl)-2,5-dihydro-pyrrole-1-carboxylic acid methyl ester 
• 856438-51-2 2-(2-benzyloxyphenyl)pyrrole-1-carboxylic acid methyl ester 
• 856438-49-8 allyl-[1-(2-benzyloxy-phenyl)-prop-2-ynyl]-carbamic acid methyl ester 
• 856438-48-7 allyl-[1-(2-benzyloxy-phenyl)-3-trimethylsilanyl-prop-2-ynyl]-carbamic acid methyl ester 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 69640-32-0 2-(2-methoxyphenyl)pyrrole 
• 190273-04-2 methyl 2-(2-methoxyphenyl)-1H-pyrrole-3-carboxylate 
• 100200-70-2 N-(2-methoxyphenyl)methylidene-4-methylbenzenesulfonamide 

Downstream Products

• 882-33-7 diphenyldisulfane 
• 10245-83-7 3,4,5-Tribrom-2-(3',5'-dibrom-2'-methoxyphenyl)-1H-pyrrol 

Relevant articles and documents

Two-step total synthesis of an anti-MRSA and myosin-inhibiting marine natural product pentabromopseudilin via Suzuki-Miyaura coupling of a MIDA boronate ester

A marine natural product isolated from Pseudoalteromonas sp., pentabromopseudilin, with promising anti-MRSA and myosin ATPase inhibition activities was synthesized in two steps using recently developed MIDA boronate Suzuki-Miyaura coupling technology. Add

Silver(I)-catalyzed route to pyrroles: Synthesis of halogenated pseudilins as allosteric inhibitors for myosin atpase and x-ray crystal structures of the protein-inhibitor complexes

The pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a new class of isoform-specific allosteric inhibitors of myosin ATPase. Herein, we describe an application of the silver(I)-catalyzed cycloisomerizati

MEANS FOR TREATING MYOSIN-RELATED DISEASES

The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selec