1024500-31-9Relevant articles and documents
INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE
-
Page/Page column 30, (2008/12/05)
Compounds of formula (I) are inhibitors of p38 MAP kinase activity, and are useful in the treatment of, inter alia, inflammatory and autoimmune disease formula (I): wherein R3, R4, R5 and R6 are each independently hydrogen or halogen; M and P are independently -N= or -CH=; Z is (a) a radical of formula R1R2CHNH-Y-L1-X1-(CH2)Z-, wherein R1R2CHNH- is an N-linked amino acid or amino acid ester group as defined in the description, and -Y-L1-X1-(CH2)Z- is a linker radical as defined in the description.