1024586-00-2

Basic information

• Product Name: 2-(5-fluorobiphenyl-2-yl)pyridine
• Synonyms: 2-(5-fluorobiphenyl-2-yl)pyridine
• CAS NO: 1024586-00-2
• Molecular Weight: 249.287
• Mol File: 1024586-00-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(5-fluorobiphenyl-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-fluorobiphenyl-2-yl)pyridine(1024586-00-2)
• EPA Substance Registry System: 2-(5-fluorobiphenyl-2-yl)pyridine(1024586-00-2)

Safety Data

• Hazardous Substances Data: 1024586-00-2(Hazardous Substances Data)

Upstream product

• 62673-29-4 phenyl(diisobutyl)aluminium 
• 391604-55-0 2-(2,4-difluorophenyl)pyridine 
• 109-04-6 2-bromo-pyridine 
• 100-59-4 phenylmagnesium chloride 
• 144025-03-6 2,4-difluorophenylboronic acid 
• 58861-53-3 4-fluorophenylpyridine 

Relevant articles and documents

Ligand-induced reactivity of β-diketiminate magnesium complexes for regioselective functionalization of fluoroarenes: Via C-H or C-F bond activations

Using β-diketiminate Mg(ii) complexes containing either alkyl, aryl or amide groups, the regioselective functionalization of a wide range of fluoroarenes is accomplished but in uniquely different ways. Overcoming common limitations of traditional s-block bases, kinetically activated [(DippNacnac)Mg(TMP)] (1) deprotonates these molecules at room temperature, trapping sensitive fluoroaryl anions that can then engage in Negishi cross-coupling; whereas [(DippNacnac)Mg(R)THF] (R = nBu, Ph, benzofuryl) have proved to be effective reagents for C-F bond alkylation/arylation via pyridine directed C-F bond cleavage.

Noncatalytic pyridyl-directed alkylation and arylation carbon-fluorine bond of polyfluoroarenes with grignard reagents

Cross-coupling reaction of polyfluoroarenes with Grignard reagents via pyridine-directed cleavage of C-F bond in the absence of metal catalysts was developed. A possible mechanism was suggested.