1024592-54-8 Usage
Description
BenzaMide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrois a complex organic compound with a specific chemical structure. It is characterized by its amide and nitro groups, as well as its dihydro-isoquinolinyl and dimethoxy-phenyl moieties. BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitrois known for its potential applications in the pharmaceutical industry, particularly in the development of drugs targeting cancer.
Uses
1. Used in Pharmaceutical Industry:
BenzaMide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrois used as an intermediate in the synthesis of Tariquidar (T007600) for the following reasons:
a. Tariquidar is a P-glycoprotein drug efflux pump inhibitor, which plays a crucial role in the development of multidrug resistance in cancer cells. By inhibiting this pump, Tariquidar can increase the effectiveness of chemotherapeutic drugs and potentially improve treatment outcomes for cancer patients.
b. The compound's unique chemical structure allows it to be a key component in the synthesis of Tariquidar, contributing to its overall pharmacological properties and efficacy.
2. Used in Cancer Treatment:
BenzaMide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrois used as a precursor in the development of cancer treatment options, specifically through its role in the synthesis of Tariquidar. The application reason is as follows:
a. As a P-glycoprotein inhibitor, Tariquidar can help overcome multidrug resistance in cancer cells, allowing for more effective treatment with conventional chemotherapeutic agents.
b. The compound's involvement in the synthesis of Tariquidar highlights its potential contribution to the development of novel cancer therapies and the improvement of existing treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 1024592-54-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,4,5,9 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1024592-54:
(9*1)+(8*0)+(7*2)+(6*4)+(5*5)+(4*9)+(3*2)+(2*5)+(1*4)=128
128 % 10 = 8
So 1024592-54-8 is a valid CAS Registry Number.
1024592-54-8Relevant articles and documents
DEUTERATED ANALOGS OF TARIQUIDAR
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Paragraph 0312-0313, (2019/11/22)
The present invention relates to efflux inhibitor compounds, compositions, and methods of using the same. More specifically, the instant invention comprises deuterated analogs of tariquidar with superior pharmacokinetic properties such that it is now poss
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators
Klinkhammer, Werner,Mueller, Henrik,Globisch, Christoph,Pajeva, Ilza K.,Wiese, Michael
experimental part, p. 2524 - 2535 (2009/09/05)
The development of new modulators possessing high efficacy, low toxicity and high selectivity is a pivotal approach to overcoming P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in tumour cells. In this study 39 compounds are presented which hav
