1025097-90-8Relevant articles and documents
5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE-DERIVATIVES AND THEIR USES AS ANTIBACTERIALS
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, (2009/10/06)
The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; Rsup
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: Influence of the central spacer on the antibacterial activity and the mode of action
Hubschwerlen, Christian,Specklin, Jean-Luc,Baeschlin, Daniel K.,Borer, Yves,Haefeli, Sascha,Sigwalt, Christine,Schroeder, Susanne,Locher, Hans H.
, p. 4229 - 4233 (2007/10/03)
Oxazolidinone-quinolone hybrids, which combine the pharmacophores of a quinolone and an oxazolidinone, were synthesised and shown to be active against a variety of susceptible and resistant Gram-positive and Gram-negative bacteria. The nature of the space