10252-57-0

Basic information

• Product Name: 3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole
• Synonyms: 3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole
• CAS NO: 10252-57-0
• Molecular Weight: 186.257
• Mol File: 10252-57-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole(10252-57-0)
• EPA Substance Registry System: 3,4,5‐trimethyl‐1‐phenyl‐1H-pyrazole(10252-57-0)

Safety Data

• Hazardous Substances Data: 10252-57-0(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 1522-25-4 4-hydroxy-3-methylpent-3-en-2-one 
• 947-82-0 4,4,5-trimethyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 7789-60-8 phosphorus tribromide 
• 7664-93-9 sulfuric acid 
• 13295-23-3 4,4,5-trimethyl-2-phenyl-3,4-dihydro-2H-pyrazol-3-ol 
• 7647-01-0 hydrogenchloride 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 931-55-5 phenyl-diazene 
• 1131-47-1 2,4-dimethyl-6,7-benzo-1,5-diazepine 
• 66068-54-0 2,3,4-trimethyl-3H-benzo[b][1,4]diazepine 
• 59-88-1 phenylhydrazine hydrochloride 
• 72358-76-0 phenylhydrazine acetate 

Relevant articles and documents

Preparation method of pyrazole derivative

The present invention discloses a method for preparing a pyrazole derivative. The method comprises the following steps: the arylhydrazine derivative is mixed with an alkyldione derivative, reaction, to obtain a pyrazole derivative; wherein the structure of the arylhydrazine derivative is as follows: the structure of the alkyldione derivative is as follows: the structure of the pyrazole derivative provided by the present invention is green safe, simple and efficient, mild conditions, no catalyst, low cost, high synthesis efficiency. This method can synthesize a variety of 1,3,4,5-tetra-substituted pyrazole derivatives, and the method can be widely used in the field of organic synthesis.

Cu1.5PMo12O40-catalyzed condensation cyclization for the synthesis of substituted pyrazoles

A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu1.5PMo12O40 (0.33?mol%) under mild conditions (r.t.-60?°C, 10–30?min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles.

2 (Oxa) as a heterogeneous recyclable catalyst: Synthesis of pyrazoles under mild reaction conditions

We developed a novel and highly efficient protocol for the synthesis of important pyrazole derivatives by using some 1,3-dicarbonyl compounds and phenyl hydrazines via a one-pot protocol. As a recyclable heterogeneous catalyst, we used [Ce(l-Pro)2]2 (Oxa). In addition, the catalyst is recyclable, the proline is economically viable and readily available in both enantiomeric forms and the catalyst is insoluble in almost all solvents and may be easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion, short reaction times, a straightforward procedure and cleaner reaction profiles.