1025504-52-2

Basic information

• Product Name: 6-[(methoxycarbonylmethyl)sulfanylmethyl]-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine
• Synonyms: 6-[(methoxycarbonylmethyl)sulfanylmethyl]-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine
• CAS NO: 1025504-52-2
• Molecular Weight: 590.657
• Mol File: 1025504-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[(methoxycarbonylmethyl)sulfanylmethyl]-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(methoxycarbonylmethyl)sulfanylmethyl]-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine(1025504-52-2)
• EPA Substance Registry System: 6-[(methoxycarbonylmethyl)sulfanylmethyl]-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine(1025504-52-2)

Safety Data

• Hazardous Substances Data: 1025504-52-2(Hazardous Substances Data)

Upstream product

• 865434-80-6 6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine 
• 2365-48-2 Methyl thioglycolate 

Relevant articles and documents

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

An efficient and facile synthesis of a large series of diverse 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides (55 examples of both ribo- and 2′-deoxyribonucleosides), aimed at identifying novel homologues of natural nucleosides, was developed. The key transformation involved nucleophilic substitutions of Tol-protected 6-(mesyloxymethyl)purine nucleosides by primary or secondary amines, alcoholates or thiolates. While the 2′-deoxyribonucleosides were inactive, the ribonucleosides exerted considerable cytostatic effects and some anti-HCV activity with low selectivity.