10256-00-5

Basic information

• Product Name: malonic-n,n’-dicyclohexyldiamide
• Synonyms: malonic-n,n’-dicyclohexyldiamide;n,n’-dicyclohexyl-propanediamid;N,N'-dicyclohexylpropanediamide
• CAS NO: 10256-00-5
• Molecular Formula: C₁₅H₂₆N₂O₂
• Molecular Weight: 266.382
• EINECS: 210-670-8
• Mol File: 10256-00-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 557.8°Cat760mmHg
• Flash Point: 229.9°C
• Appearance: /
• Density: 1.271g/cm³
• Vapor Pressure: 3.25E-11mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: malonic-n,n’-dicyclohexyldiamide(CAS DataBase Reference)
• NIST Chemistry Reference: malonic-n,n’-dicyclohexyldiamide(10256-00-5)
• EPA Substance Registry System: malonic-n,n’-dicyclohexyldiamide(10256-00-5)

Safety Data

• Hazardous Substances Data: 10256-00-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H26N2O2/c18-14(16-12-7-3-1-4-8-12)11-15(19)17-13-9-5-2-6-10-13/h12-13H,1-11H2,(H,16,18)(H,17,19)

Upstream product

• 49754-15-6 malonyldiurethane 
• 108-91-8 cyclohexylamine 
• 105-53-3 diethyl malonate 
• 73453-46-0 Acetyl-N,N'-dicyclohexylmalonamide 
• 73453-43-7 Ethyl Acetyl-N-cyclohexylmalonamate 
• 111-27-3 hexan-1-ol 
• 3173-53-3 Cyclohexyl isocyanate 

Downstream Products

• 54535-29-4 1-cyclohexyl-2,4,5-trioxo-pyrrolidine-3-carboxylic acid cyclohexylamide 
• 13381-09-4 1,1,3,3-Tetrakis-cyclohexylcarbamoyl-propan 

Relevant articles and documents

N,N'-Disubstituted Dithiomalonamide Complexes of Antimony(III). Crystal and Molecular Structure of with Lone-pair Occupation of an Antimony Co-ordination Site

Direct addition of antimony(III) trichloride to N,N'-disubstituted dithiomalonamides, RHNC(S)CH2C(S)NHR (R = CH3, C2H5, i-C3H7, n-C4H9, or cyclo-C6H11), gives rise to 1:1 complexes.I.r. and n.m.r. data suggest that the complexes have equivalent structures

New derivatives of oxazolidinedione and pyrrolidinetrione as potential antiinflammatory agents

Syntheses of new derivatives of oxazolidinedione and pyrrolidinetrione as potential antiinflammatory agents are described. Dicyclohexylsuccindiamide and dicyclohexylmalondiamide when condensed with oxalyl dichloride afforded ethanediylidenebis (3 cyclohexyloxazolidine 4,5 dione) (I) and 1 cyclohexyl 2,4,5 trioxopyrrolidine 3 N cyclohexylcarboxamide (IX), respectively. Compound (I) when treated with sodium ethoxide isomerized to 4,4 bi [1 cyclohexyl 2,3,5 trioxopyrrolidinyl] (II). N Cyclohexylacetamide and oxalyl dichloride gave 2 methylene 3 cyclohexyloxazolidine 4,5 dione (IV) which was obtained also on condensing sodium N cyclohexylacetamide enolate with oxalyl dichloride. Compound (IV) when treated with sodium ethoxide afforded 1 cyclohexyl 3 (1 cyclohexylpyrrolidine 2,3,5 trione 4 ylidenyl)pyrrolidine 2,5 dione 3 ylidene (VIII) which was synthesized also by condensing cyclohexylamine with diethyl oxalacetate in the presence of sodium ethoxide or from N cyclohexylacetamide and ethyl oxalate. Pharmacologic testing revealed strong antiinflammatory activity of compound III (the sodium derivative of II) and of IV and IX whereas the other compounds showed low absorption and were not further examined.