1025721-01-0

Basic information

• Product Name: 4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide
• Synonyms: 4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide
• CAS NO: 1025721-01-0
• Molecular Weight: 281.674
• Mol File: 1025721-01-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide(1025721-01-0)
• EPA Substance Registry System: 4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide(1025721-01-0)

Safety Data

• Hazardous Substances Data: 1025721-01-0(Hazardous Substances Data)

Upstream product

• 959578-03-1 3,4-dichloropyridine-2-carboxylic acid 
• 55934-00-4 3,4-dichloropyridine 
• 403-19-0 2-fluoro-4-nitrophenol 
• 1025720-99-3 3,4-dichloropyridine-2-carboxamide 
• 399-96-2 4-amino-2-fluorophenol 

Downstream Products

• 1025721-13-4 3-chloro-4-(4-(4-chloro-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2-fluorophenoxy)picolinamide 
• 1025721-12-3 3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-picolinamide 
• 1025721-14-5 3-chloro-4-(4-(4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamido)-2-fluorophenoxy)picolinamide 
• 1552280-90-6 3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 1612842-41-7 3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)phenoxy)picolinamide 
• 1612842-46-2 N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide 
• 1612842-43-9 3-chloro-4-(4-(3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)-2-fluorophenoxy)-picolinamide 
• 1612842-49-5 N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide 
• 1612842-13-3 3-chloro-4-(2-fluoro-4-(2-(N-phenylsulfamoyl)acetamido)phenoxy)picolinamide 
• 1612842-14-4 3-chloro-4-(2-fluoro-4-(2-(N-(p-tolyl)sulfamoyl)acetamido)phenoxy)picolinamide 
• 1612842-15-5 3-chloro-4-(2-fluoro-4-(2-(N-(4-fluorophenyl)sulfamoyl)acetamido)phenoxy)picolinamide 
• 1612842-16-6 N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-phenyl-1,2-thiazinane-6-carboxamide 1,1-dioxide 
• 1612842-17-7 N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide 
• 1612842-18-8 N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(4-fluorophenyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide 

Relevant articles and documents

PHOSPHONATE CONJUGATES AND USES THEREOF

Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

Antitumor compound used as AXL inhibitor and application of antitumor compound

The invention discloses a compound shown in a general formula (I) or pharmaceutically acceptable salt of the compound and preparation methods of the compound and the salt, and further discloses pharmaceutical composition containing the compound and an application of the compound and the pharmaceutical composition in preparation of an AXL inhibitory drug. The AXL inhibitory drug is used for treating tumor, nephropathy, immune system disease or circulatory system disease.

PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.