1025721-07-6

Basic information

• Product Name: 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde
• Synonyms: 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde
• CAS NO: 1025721-07-6
• Molecular Weight: 343.096
• Mol File: 1025721-07-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde(1025721-07-6)
• EPA Substance Registry System: 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde(1025721-07-6)

Safety Data

• Hazardous Substances Data: 1025721-07-6(Hazardous Substances Data)

Usage

Description

1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde is a chemical compound characterized by its molecular formula C12H8FINO2. It is a yellow solid with a molecular weight of 381.1 g/mol. 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde is a derivative of pyridine and features a fluorophenyl group, a dihydro-4-iodo-2-oxopyridine-3-carboxaldehyde group, and a carbonyl group. Its specific applications and properties are contingent upon the particular reactions and processes it is involved in.

Uses

Used in Organic Synthesis:
1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde is used as an intermediate in organic synthesis for the creation of various complex molecules. Its unique structure allows for a range of chemical reactions, making it a valuable component in the synthesis of advanced organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde is utilized as a key compound in the research and development of new drugs and treatments. Its structural diversity and reactivity contribute to the design and synthesis of potential therapeutic agents.
Used in Drug Development:
1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde has potential applications in the development of new drugs due to its structural features and reactivity. It can be employed in the design of novel pharmaceuticals targeting specific diseases or conditions, with the aim of improving treatment options and patient outcomes.

Upstream product

• 1628-89-3 2-methoxypyridine 
• 158669-26-2 4-iodo-2-methoxynicotinaldehyde 
• 726206-53-7 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 1025721-10-1 1-(4-fluoro-phenyl)-4-iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 
• 1025721-21-4 1-(4-fluoro-phenyl)-4-iodo-2-oxo-1,2-dihydro-pyridine-3-carbonyl chloride 
• 1439876-98-8 N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-(ethylamino)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439878-75-7 N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439878-82-6 1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxylic acid [4-(2-acetylaminopyridin-4-yloxy)-2,5-difluorophenyl]amide 
• 1439877-05-0 N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1025720-94-8 BMS-777607 
• 1025721-12-3 3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamido)phenoxy)-picolinamide 

Relevant articles and documents

PHOSPHONATE CONJUGATES AND USES THEREOF

Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Formula (I). Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4- ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the met kinase superfamily

Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)- 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were identified as potent and selective Met kinase inhibitors. Substitution of the pyridine 3-position gave improved enzyme potency, while substitution of the pyridone 4-position led to improved aqueous solubility and kinase selectivity. Analogue 10 demonstrated complete tumor stasis in a Met- dependent GTL-16 human gastric carcinoma xenograft model following oral administration. Because of its excellent in vivo efficacy and favorable pharmacokinetic and preclinical safety profiles, 10 has been advanced into phase I clinical trials.