1025807-09-3

Basic information

• Product Name: [(2-Amino-3,4-dioxo-cyclobut-1-enyl)-benzyl-amino]-acetic acid tert-butyl ester
• CAS NO: 1025807-09-3
• Molecular Weight: 316.357
• Mol File: 1025807-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2-Amino-3,4-dioxo-cyclobut-1-enyl)-benzyl-amino]-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2-Amino-3,4-dioxo-cyclobut-1-enyl)-benzyl-amino]-acetic acid tert-butyl ester(1025807-09-3)
• EPA Substance Registry System: [(2-Amino-3,4-dioxo-cyclobut-1-enyl)-benzyl-amino]-acetic acid tert-butyl ester(1025807-09-3)

Safety Data

• Hazardous Substances Data: 1025807-09-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 144913-06-4 3-(benzylamino)-4-ethoxycyclobut-3-ene-1,2-dione 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 1027904-37-5 [Benzyl-(2-ethoxy-3,4-dioxo-cyclobut-1-enyl)-amino]-acetic acid tert-butyl ester 

Relevant articles and documents

Bioisosteric replacement of the α-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene- 1,2-dione containing NMDA antagonists

In this report, a novel bioisostere of the α-amino acid, 3,4-diamino-3- cyclobutene-1,2-dione, has been incorporated into a series of compounds which are NMDA antagonists. These compounds, which are achiral and easily prepared, demonstrated good affinity at the NMDA receptor by their ability to displace [3H]CPP binding in vitro. In particular, the phosphonic acid 24 provided protection against NMDA-induced lethality in mice equivalent to 2-amino-7- phosphonoheptanoic acid (5). This was considered an encouraging result in lieu of the fact that 24, like 5, lacks the conformational rigidity of the more potent NMDA antagonists. In addition, analogs that incorporate the 1,2,4-oxadiazolidine-3,5-dione heterocycle of quisqualic acid and the unsaturation of kainic acid were prepared to explore selectivity at the non- NMDA receptor subtypes.