1025821-33-3

Basic information

• Product Name: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one
• Synonyms: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one
• CAS NO: 1025821-33-3
• Molecular Weight: 401.276
• Mol File: 1025821-33-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 281 - 282oC
• Boiling Point: 574.8±60.0 °C(Predicted)
• Density: 1.55±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one(1025821-33-3)
• EPA Substance Registry System: (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one(1025821-33-3)

Safety Data

• Hazardous Substances Data: 1025821-33-3(Hazardous Substances Data)

Usage

Description

(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is a complex organic compound with a unique molecular structure that features a thiazolone core, a quinoxaline moiety, and a dichlorophenyl group. (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is characterized by its potential biological activity and selectivity, making it a promising candidate for various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is used as a potent and selective DYRK inhibitor for [application reason]. It exhibits high potency against DYRK3 (IC50 = 0.7 nM) and similar activity against DYRK1 and DYRK2, while showing ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. This selective inhibition makes it a valuable tool in the development of targeted therapies for various diseases.
Used in Hematological Applications:
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is used to enhance the number of CFU-E stimulated by Epo from human marrow for [application reason]. This property suggests its potential use in the treatment of anemia and other blood-related disorders, as it can help improve the production of red blood cells.
Used in Anemia Treatment:
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is used to increase hemoglobin levels in anemic mice for [application reason]. Its ability to raise hemoglobin levels indicates its potential as a therapeutic agent for anemia, which can be particularly beneficial for patients suffering from chronic anemia or those undergoing treatments that cause anemia as a side effect.
Used in Drug Development:
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is used as a starting point for the development of new drugs for [application reason]. Its unique structure and biological activity make it an attractive candidate for further research and optimization, with the potential to lead to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Chemical Research:
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one is used as a research tool in chemical and biological studies for [application reason]. Its complex structure and potential interactions with various biological targets make it a valuable compound for understanding the mechanisms of action and developing new strategies for drug design and synthesis.

Upstream product

• 936638-01-6 2-(2,6-dichlorophenylamino)thiazol-4(5H)-one 
• 130345-50-5 quinoxaline-6-carbaldehyde 

Relevant articles and documents

5(Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,6-DICHLOROPHENYL)AMINO]-1,3-THIAZOL-4(5H)-ONE

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