1025908-97-7

Basic information

• Product Name: 6-benzyloxy-5-(2,4-dimethoxy-phenyl)-4-methoxy-benzo[1,3]dioxole
• Synonyms: 6-benzyloxy-5-(2,4-dimethoxy-phenyl)-4-methoxy-benzo[1,3]dioxole
• CAS NO: 1025908-97-7
• Molecular Weight: 394.424
• Mol File: 1025908-97-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-benzyloxy-5-(2,4-dimethoxy-phenyl)-4-methoxy-benzo[1,3]dioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyloxy-5-(2,4-dimethoxy-phenyl)-4-methoxy-benzo[1,3]dioxole(1025908-97-7)
• EPA Substance Registry System: 6-benzyloxy-5-(2,4-dimethoxy-phenyl)-4-methoxy-benzo[1,3]dioxole(1025908-97-7)

Safety Data

• Hazardous Substances Data: 1025908-97-7(Hazardous Substances Data)

Upstream product

• 251920-24-8 6-benzyloxy-4-methoxy-benzo[1,3]dioxole 
• 100-39-0 benzyl bromide 
• 50901-34-3 3-methoxy-4,5-methylenedioxyphenol 
• 133730-34-4 2,4-dimethoxyphenylboronic acid 
• 229012-10-6 5-bromo-6-benzyloxy-4-methoxy-1,3-benzodioxole 

Relevant articles and documents

Total synthesis of a natural antioxidant and structure-activity relationships of related compounds

A total synthesis of benzodioxole derivative 1 was achieved via a palladium(0)-catalyzed cross-coupling reaction in a 68% overall yield (4 steps). A novel series of benzodioxoles bearing a variety of aromatic and heterocyclic rings was also prepared and the antioxidative activity evaluated using in vitro model systems. Structure-activity studies revealed that i) intramolecular hydrogen-bonding in the phenol moiety reduced activity, ii) introduction of disubstituents at the ortho location relative to the phenol increased activity, and iii) the methylenedioxy function contributed to stabilization of the phenoxy radical. Among of these compounds, 5,7-di-(4- methoxyphenyl)-4-methoxy-6-hydroxy-1,3-benzodioxole (7p) was the most favorable agent and more potent than n-propyl gallate.