1026029-33-3Relevant articles and documents
Preparation method of JAK inhibitor momelotinib
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Paragraph 0041; 0044-0051, (2020/05/14)
The invention relates to a preparation method of a JAK inhibitor momelotinib. The preparation method provided by the invention has the advantages of simple preparation route, mild preparation conditions, cheap and easily available raw materials and relatively low synthesis cost.
DEUTERATED PHENYL AMINO PYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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Paragraph 0078, (2015/12/18)
The present invention relates to a deuterated phenyl amino pyrimidine compound and pharmaceutical composition containing the same. Specifically provided are a deuterated phenyl amino pyrimidine compound as represented by formula (I), and pharmaceutical composition containing the compound, or polymorph, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound of the present invention can treat and/or prevent JAK kinase-related diseases, such as bone marrow proliferative disease, cancer, immunologic diseases and the like.
Convenient preparation of 4-aryl-2-(heteroarylamino)pyrimidines and 4-anilino-2-(heteroarylamino)pyrimidines
Bliss, Brian I.,Ahmed, Feryan,Iyer, Subashree,Lin, Weimin,Walker, Joel,Zhao, He
supporting information; experimental part, p. 3259 - 3262 (2010/07/10)
4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many drug-like molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl- and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatures under sealed tube conditions is reported. This method's convenience and practicality is demonstrated through the preparation of several novel non-nucleoside reverse transcriptase inhibitor (NNRTI) analogues.