102619-80-7

Basic information

• Product Name: MOUSE IL-4
• Synonyms: RMIL-4;MIL-4;MURINE BCDF;MURINE B CELL STIMULATING FACTOR;MURINE BCGF;MURINE BSF-1;MURINE INTERLEUKIN-4;MURINE IL-4
• CAS NO: 102619-80-7
• Molecular Formula: C16H30N6O3S
• Molecular Weight: 386.5128
• Product Categories: cytokine
• Mol File: 102619-80-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 806.2 °C at 760 mmHg
• Flash Point: 441.4 °C
• Appearance: /
• Density: 1.22 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: MOUSE IL-4(CAS DataBase Reference)
• NIST Chemistry Reference: MOUSE IL-4(102619-80-7)
• EPA Substance Registry System: MOUSE IL-4(102619-80-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 102619-80-7(Hazardous Substances Data)

Usage

Description

MOUSE IL-4, also known as Murine Interleukin-4, is a cytokine protein derived from mice that plays a crucial role in the immune system. It is involved in the regulation of T-helper cell differentiation, B-cell proliferation, and class switch recombination. MOUSE IL-4 exhibits pleiotropic effects on various immune cells, making it a valuable tool for research and therapeutic applications.
Source:
MOUSE IL-4 is typically sourced from mice, specifically from their immune cells, and can be produced through recombinant DNA technology.
Production Methods:
MOUSE IL-4 can be produced using recombinant DNA technology, where the gene encoding for the protein is inserted into a suitable expression system, such as bacteria or yeast, to produce large quantities of the protein.

Uses

Used in Immunology Research:
MOUSE IL-4 is used as a research tool for studying the immune system, particularly in the context of T-helper cell differentiation, B-cell proliferation, and class switch recombination. It helps researchers understand the complex interactions between immune cells and their role in immune responses.
Used in Cell Culture Media:
MOUSE IL-4 is used as a component of cell culture media for class switch recombination assays. It is added to the media to stimulate B cells to undergo class switch recombination, which is an essential process in the production of different types of antibodies.
Used in Mucosal Healing Studies:
MOUSE IL-4 is used to study its therapeutic benefits for mucosal healing. It has been shown to promote wound healing and tissue regeneration in various mucosal tissues, making it a potential candidate for the development of treatments for inflammatory bowel disease and other mucosal disorders.
Used as a Pioglitazone or New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11):
MOUSE IL-4 is used as a pioglitazone or a new peroxisome proliferator-activated receptor agonist (GQ-11) for the treatment of various diseases. Pioglitazone is a medication used to treat type 2 diabetes, while GQ-11 is a novel PPAR agonist with potential therapeutic applications in various inflammatory and metabolic disorders.

Biochem/physiol Actions

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.