1026273-53-9

Basic information

• Product Name: (E)-3-(4-Acetylamino-phenylamino)-hex-2-enoic acid methyl ester
• CAS NO: 1026273-53-9
• Molecular Weight: 276.335
• Mol File: 1026273-53-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(4-Acetylamino-phenylamino)-hex-2-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(4-Acetylamino-phenylamino)-hex-2-enoic acid methyl ester(1026273-53-9)
• EPA Substance Registry System: (E)-3-(4-Acetylamino-phenylamino)-hex-2-enoic acid methyl ester(1026273-53-9)

Safety Data

• Hazardous Substances Data: 1026273-53-9(Hazardous Substances Data)

Upstream product

• 30414-54-1 methyl 3-oxohexanoate 
• 122-80-5 N-acetyl-p-phenylenediamine 

Relevant articles and documents

4-Aminoquinolines: Novel nociceptin antagonists with analgesic activity

Small-molecule nociceptin antagonists were synthesized to examine their therapeutic potential. After a 4-aminoquinoline derivative was found to bind with the human ORL1 receptor, a series of 4-aminoquinolines and related compounds were synthesized and their binding was evaluated. Elucidation of structure - Activity relationships eventually led to the optimum compounds. One of these compounds, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide hydrochloride (11) not only antagonized nociceptin-induced allodynia in mice but also showed analgesic effect in a hot plate test using mice and in a formalin test using rats. Its analgesic effect was not antagonized by the opioid antagonist naloxone. These results indicate that this nociceptin antagonist has the potential to become a novel type of analgesic that differs from μ-opioid agonists.