102629-74-3Relevant articles and documents
γ-Aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: Amides and hydroxamates
Locock, Katherine E. S.,Yamamoto, Izumi,Tran, Priscilla,Hanrahan, Jane R.,Chebib, Mary,Johnston, Graham A. R.,Allan, Robin D.
, p. 5626 - 5630 (2013/07/26)
Series of compounds were generated via the bioisosteric replacement of the carboxylate of 4-ACPCA (2) with hydroxamate or amide groups. All compounds from this study exhibited increased selectivity for GABAC, the most potent being 4-ACPHA (10a, IC50 = 13 μM) and 4-ACPAM (11a, IC 50 = 10 μM). This provides evidence that a zwitterionic structure is not essential for GABAC antagonists, rather the emphasis lies in appropriate heteroatoms to participate in hydrogen bonding.
Synthesis of analogues of GABA. XV. Preparation and resolution of some potent cyclopentene and cyclopentane derivatives
Allan,Fong
, p. 855 - 864 (2007/10/02)
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Synthesis of analogues of GABA. IV. Three unsaturated derivatives of 3-aminocyclopentane-1-carboxylic acid
Allan,Twitchin
, p. 599 - 604 (2007/10/02)
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