10265-83-5Relevant articles and documents
Nanocrystalline aluminium oxide: A mild and efficient reusable catalyst for the one-pot synthesis of poly-substituted quinolines via Friedlander hetero-annulation
Sadjadi, Sodeh,Shiri, Soudeh,Hekmatshoar, Rahim,Beheshtiha, Yahya S.
, p. 1343 - 1347 (2009)
o-Aminoaryl ketones undergo smooth condensation with α-methylene ketones in the presence of nanocrystalline aluminium oxide under mild reaction conditions to afford the corresponding poly-substituted quinolines in excellent yields. The catalyst can be rec
Water mediated synthesis of substituted quinolines - A new green approach to the Friedlaender annulation
Selvam, Nagarajan Panneer,Saravanan, Chandramathi,Muralidharan,Perumal, Paramasivan T.
, p. 1379 - 1382 (2006)
A new green approach to the Friedlaender Quinoline synthesis is described for the preparation of polysubstituted quinolines from o-amino aryl ketones and carbonyl compounds containing active methylene group mediated by water and catalysed by KHSO4/s
A simple, efficient and solvent-free protocol for the friedlaender synthesis of quinolines by using SnCl2·2H2O
Arumugam, Pandurangan,Karthikeyan, Ganesan,Atchudan, Raji,Muralidharan,Perumal, Paramasivan T.
, p. 314 - 315 (2005)
A variety of polysubstituted quinolines have been synthesized under solvent free condition by using tin(II) chloride-dihydrate. The reaction proceeds smoothly at room temperature in short reaction time. The yields and purity are excellent. Copyright
Efficient and rapid Friedlander synthesis of functionalized quinolines catalyzed by neodymium(III) nitrate hexahydrate
Varala, Ravi,Enugala, Ramu,Adapa, Srinivas R.
, p. 3825 - 3830 (2006)
Friedlander synthesis of quinolines catalyzed by neodymium nitrate [Nd(NO3)3·6H2O, 5 mol%] in ethanol at room temperature was achieved in moderate to excellent yields (62-94%). Georg Thieme Verlag Stuttgart.
Solid-Phase Friedl?nder Synthesis Using an Alkoxyamine Linker
Yamaguchi, Kota,Noda, Takeshi,Tomizawa, Toshiki,Kanai, Eriko,Hioki, Hideaki
, p. 4990 - 4995 (2015)
A quinoline library was prepared by combinatorial synthesis using an alkoxyamine linker. Substrates were loaded onto a solid support containing an oxime linkage. After selected reactions on the solid support, the products were cleaved by a Friedl?nder-typ
Iron(III) chloride-promoted, solvent-free, facile, and efficient Friedlaender synthesis of quinolines
Kumar, Sanjay,Saini, Anil,Sandhu, Jagir S.
, p. 4071 - 4078 (2007)
A mild, efficient, and solvent-free version of Friedlaender annulation of 2-amino ketones and α-methylene carbonyl compounds for the synthesis of polysubstituted quinolines using a catalytic amount of commercially available iron(III) chloride at room temp
Nickel nanoparticles: A highly efficient and retrievable catalyst for the solventless Friedlander annulation of quinolines and their in silico molecular docking studies as histone deacetylase inhibitors
Angajala, Gangadhara,Subashini, Radhakrishnan
, p. 45599 - 45610 (2015)
The present work explores a highly efficient, environmental friendly, green, solvent-free protocol for the preparation of polysubstituted quinolines via Friedlander annulation using nickel nanoparticles (80-100 nm) biofabricated from Aegle Marmelos Correa
Direct synthesis of ring-fused quinolines and pyridines catalyzed byNNHY-ligated manganese complexes (Y = NR2or SR)
Han, Mingyang,Lin, Qing,Liu, Qingbin,Liu, Song,Ma, Ning,Solan, Gregory A.,Sun, Wen-Hua,Wang, Zheng,Yan, Xiuli
, p. 8026 - 8036 (2021/12/27)
Four cationic manganese(i) complexes, [(fac-NNHN)Mn(CO)3]Br (Mn-1-Mn-3) and [(fac-NNHS)Mn(CO)3]Br (Mn-4) (whereNNHis a 5,6,7,8-tetrahydro-8-quinolinamine moiety), have been synthesized and evaluated as catalysts for the direct synthesis of quinolines and pyridines by the reaction of a γ-amino alcohol with a ketone or secondary alcohol;NNHS-ligatedMn-4proved the most effective of the four catalysts. The reactions proceeded well in the presence of catalyst loadings in the range 0.5-5.0 mol% and tolerated diverse functional groups such as alkyl, cycloalkyl, alkoxy, chloride and hetero-aryl. A mechanism involving acceptorless dehydrogenation coupling (ADC) has been proposed on the basis of DFT calculations and experimental evidence. Significantly, this manganese-based catalytic protocol provides a promising green and environmentally friendly route to a wide range of synthetically important substituted monocyclic, bicyclic as well as tricyclicN-heterocycles (including 50 quinoline and 26 pyridine examples) with isolated yields of up to 93%.
Magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid as a highly efficient and green heterogeneous catalyst for the synthesis of substituted quinolines and 1-amidoalkyl-2-naphthol derivatives
Katheriya, Deepak,Patel, Nipun,Dadhania, Harsh,Dadhania, Abhishek
, p. 805 - 816 (2020/10/02)
Abstract: Magnetically retrievable, magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid (DDBSA@MNP) was synthesized and characterized through different analytical techniques such as TEM, XRD, FTIR, TGA, SEM, EDX and
Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities
Akkachairin, Bhornrawin,Mungthin, Mathirut,Reamtong, Onrapak,Rodphon, Warabhorn,Ruchirawat, Somsak,Thongsornkleeb, Charnsak,Tummatorn, Jumreang
, (2020/03/13)
This study reported the discovery of novel compounds containing five-membered ring fused quinoline core structures as anticancer and antimalarial agents. Two libraries containing these core structures, neocryptolepines and carbocycle-fused quinolines, were prepared and evaluated. Compound 3h was found to be much more potent than other analogs against cancer cell lines with high selectivity. Meanwhile, carbocycle-fused quinolines 5h and 5s showed moderate anticancer properties but much less cytotoxicity to normal cell than doxorubicin. In addition, compound 3h also showed much lower cytotoxic against human normal kidney cell line compared to doxorubicin standard. However, only compounds 3s and 3p provided acceptable results for antimalarial activities.
