102658-00-4Relevant articles and documents
Influence of [2H]-labelled acetic acid as solvent in the synthesis of [2H]-labelled perhexiline
Schou, Soren Christian
experimental part, p. 31 - 35 (2010/04/24)
Preparation of deuterium-labelled perhexiline from an unsaturated analogue was performed via reduction with deuterium gas and PtO2 in acetic acid. Low incorporation was observed when using acetic acid as solvent (most abundant mass peak was MD0+ ), but when changing the solvent to deuterium-labelled acetic acid, e.g. acetic acid-OD or acetic acid-d4, a higher incorporation was observed (most abundant mass peak was MD8+). Using hydrogen gas instead of deuterium gas withdeuterium-labelled acetic acid, high levels of deuterium incorporation were observed (most abundant mass peak was MD5+). An attempt to reduce a precursor with a fully deuterated pyridine to obtain perhexiline with a higher content of deuterium failed. Copyright
