10268-18-5Relevant articles and documents
Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines
Kuo, Reen-Yen,Wu, Chin-Chung,Chang, Fang-Rong,Yeh, Jwu-Lai,Chen, Ing-Jun,Wu, Yang-Chang
, p. 821 - 823 (2007/10/03)
Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.