102684-91-3

Basic information

• Product Name: 2-Bromo-5-(trifluoromethyl)benzaldehyde
• Synonyms: 2-Bromo-5-(trifluoromethyl)benzaldehyde;4-Bromo-3-formylbenzotrifluoride;4-Bromo-3-formylbenzotrifluoride, 6-Bromo-alpha,alpha,alpha-trifluoro-m-tolualdehyde;2-BroMo-5-(trifluoroMethyl)benzaldehyde, 95+%
• CAS NO: 102684-91-3
• Molecular Formula: C₈H₄BrF₃O
• Molecular Weight: 253.02
• Product Categories: Aryl;Organohalides;Fluorine series
• Mol File: 102684-91-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 239.1 °C at 760 mmHg
• Flash Point: 98.4 °C
• Appearance: /
• Density: 1.677 g/cm³
• Vapor Pressure: 0.0408mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Bromo-5-(trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-(trifluoromethyl)benzaldehyde(102684-91-3)
• EPA Substance Registry System: 2-Bromo-5-(trifluoromethyl)benzaldehyde(102684-91-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 102684-91-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow liquid

InChI:InChI=1/C8H4BrF3O/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-4H

Upstream product

• 1483-55-2 2-bromo-5-trifluoromethylbenzonitrile 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 127948-49-6 2-(8-Phenyl-octa-1,7-diynyl)-5-trifluoromethyl-benzaldehyde 
• 743468-26-0 2-pent-1-ynyl-5-trifluoromethyl-benzaldehyde 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 
• 174671-50-2 5-Trifluoromethyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 905710-73-8 2-bromo-5-trifluoromethyl-1-(methoxymethoxymethyl)benzene 
• 913296-73-8 1-(2-bromo-5-(trifluoromethyl)benzyl)piperidine 
• 921219-87-6 1-(2-bromo-5-(trifluoromethyl)phenyl)-N-methylmethanamine 
• 1086429-65-3 [(2-bromo-5-trifluoromethyl-benzylidene)-amino]diphenylacetic acid allyl ester 
• 1175526-32-5 N-[2-bromo-5-(trifluoromethyl)benzyl]ethanamine 
• 1191425-85-0 C₁₁H₁₃BrF₃NSi 
• 1219936-33-0 N-benzyl-1-[2-bromo-5-(trifluoromethyl)phenyl]methanamine 
• 201929-84-2 ethyl 5-(trifluoromethyl)-1H-indole-2-carboxylate 
• 1226977-80-5 2-(2-phenyl-1-ethynyl)-5-(trifluoromethyl)benzaldehyde 
• 1229446-19-8 (E)-methyl 3-(4-trifluoro-2-formylphenyl)acrylate 

Relevant articles and documents

Mechanistic studies of copper(I)-catalyzed 1,3-halogen migration

An ongoing challenge in modern catalysis is to identify and understand new modes of reactivity promoted by earth-abundant and inexpensive first-row transition metals. Herein, we report a mechanistic study of an unusual copper(I)-catalyzed 1,3-migration of 2-bromostyrenes that reincorporates the bromine activating group into the final product with concomitant borylation of the aryl halide bond. A combination of experimental and computational studies indicated this reaction does not involve any oxidation state changes at copper; rather, migration occurs through a series of formal sigmatropic shifts. Insight provided from these studies will be used to expand the utility of aryl copper species in synthesis and develop new ligands for enantioselective copper-catalyzed halogenation.

DP2 Antagonist and Uses Thereof

Described herein is the DP2 antagonist [2′-(3-benzyl-1-ethyl-ureidomethyl)-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl]-acetic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the DP2 antagonist, or a

Discovery of INCB9471, a potent, selective, and orally bioavailable CCR5 antagonist with potent anti-HIV-1 activity

To identify a CCR5 antagonist as an HIV-1 entry inhibitor, we designed a novel series of indane derivatives based on conformational considerations. Modification on the indane ring led to the discovery of compound 22a (INCB9471) that exhibited high affinit