1027046-05-4

Basic information

• Product Name: 3-benzo[1,3]dioxol-5-yl-N-(2-bromo-4-fluoro-phenyl)-acrylamide
• CAS NO: 1027046-05-4
• Molecular Weight: 364.171
• Mol File: 1027046-05-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzo[1,3]dioxol-5-yl-N-(2-bromo-4-fluoro-phenyl)-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzo[1,3]dioxol-5-yl-N-(2-bromo-4-fluoro-phenyl)-acrylamide(1027046-05-4)
• EPA Substance Registry System: 3-benzo[1,3]dioxol-5-yl-N-(2-bromo-4-fluoro-phenyl)-acrylamide(1027046-05-4)

Safety Data

• Hazardous Substances Data: 1027046-05-4(Hazardous Substances Data)

Upstream product

• 96249-87-5 (E)-3-(1,3-benzodioxol-5-yl)acryloyl chloride 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 2373-80-0 3,4-methylenedioxy-trans-cinnamic acid 

Relevant articles and documents

Solid-phase synthesis of indol-2-ones by microwave-assisted radical cyclization

Solid-phase synthesis of indol-2-ones (2-oxindoles) by means of aryl radical cyclization of resin-bound N-(2-bromophenyl)acrylamides using Bu 3SnH is described. Among various solvents tested, DMF was found to be the best choice for the radical cyclization inducing a reagent concentration effect of the polymer support. The reaction proceeded smoothly under microwave irradiation to give the desired indol-2-ones within a very short reaction time in comparison to conventional thermal heating. In this reaction, various indol-2-ones were synthesized by using commercially available 2-bromoanilines and acryloyl chloride derivatives.