1027306-89-3

Basic information

• Product Name: ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester
• Synonyms: ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester
• CAS NO: 1027306-89-3
• Molecular Weight: 716.835
• Mol File: 1027306-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester(1027306-89-3)
• EPA Substance Registry System: ((S)-1-Benzyl-3-{(S)-1-[(S)-2-(2-benzyloxycarbonylamino-ethylcarbamoyl)-1-carbamoyl-ethylcarbamoyl]-2-phenyl-ethylamino}-2-oxo-propyl)-carbamic acid tert-butyl ester(1027306-89-3)

Safety Data

• Hazardous Substances Data: 1027306-89-3(Hazardous Substances Data)

Upstream product

• 102123-74-0 (S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate 
• 60398-41-6 (3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Relevant articles and documents

Synthesis and activity of HIV protease inhibitors

We report here the synthesis and activity of HIV protease inhibitors. In the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide. Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors.