102735-88-6

Basic information

• Product Name: 4-FLUORO-2,6-DINITROTOLUENE
• Synonyms: 4-FLUORO-2,6-DINITROTOLUENE;Benzene, 5-fluoro-2-Methyl-1,3-dinitro-;5-Fluoro-2-Methyl-1,3-dinitro-benzene;2,6-dinitro-4-fluoro-tolurene
• CAS NO: 102735-88-6
• Molecular Formula: C₇H₅FN₂O₄
• Molecular Weight: 200.12
• Mol File: 102735-88-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 282.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.497±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-FLUORO-2,6-DINITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2,6-DINITROTOLUENE(102735-88-6)
• EPA Substance Registry System: 4-FLUORO-2,6-DINITROTOLUENE(102735-88-6)

Safety Data

• Hazardous Substances Data: 102735-88-6(Hazardous Substances Data)

Usage

Description

4-FLUORO-2,6-DINITROTOLUENE is an organic compound characterized by the presence of a fluorine atom at the 4-position and two nitro groups at the 2 and 6 positions on a toluene ring. It is a versatile intermediate in the synthesis of various chemical compounds and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
4-FLUORO-2,6-DINITROTOLUENE is used as a key intermediate in the synthesis of quinazolinone derivatives, which are known as TNF-α inhibitors. These inhibitors are valuable for the treatment of cancer and inflammation, as they help regulate the immune response and reduce inflammation.
Used in Chemical Synthesis:
4-FLUORO-2,6-DINITROTOLUENE is also used as a building block in the synthesis of various organic compounds, including dyes, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a useful component in the development of new materials and products.

Upstream product

• 446-10-6 2-nitro-4-fluorotoluene 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 16024-29-6 2,6-dinitro-4-methoxytoluene 
• 16024-30-9 2-amino-4-methoxy-6-nitrotoluene 
• 93490-31-4 4-chlor-6-methoxyindol 
• 102735-89-7 2-chloro-4-methoxy-6-nitrotoluene 
• 99684-91-0 4-Chloro-2-hydroxy-6-methoxy-1-nitroso-1,2-dihydro-indol-3-one oxime 
• 168770-44-3 5-fluoro-2-methyl-3-nitroaniline 
• 168770-45-4 7-amino-5-fluoro-8-methylquinoline 
• 1389326-30-0 2-(4-fluoro-2,6-dinitrophenyl)-N,N-dimethylethenamine 
• 1389324-94-0 N-(1-(2-(4-chlorophenyl)-1-hydroxybutan-2-yl)-6-fluoro-1H-indol-4-yl)methanesulfonamide 
• 885518-25-2 6-fluoroindolamine 
• 1389326-31-1 1-(4-chlorobenzyl)-6-fluoro-1H-indol-4-amine 
• 1389326-32-2 tert-butyl 1-(4-chlorobenzyl)-6-fluoro-1H-indol-4-ylcarbamate 
• 1389326-33-3 2-(4-(tert-butoxycarbonylamino)-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetic acid 
• 1389326-34-4 methyl 2-(4-amino-6-fluoro-1H-indol-1-yl)-2-(4-chlorophenyl)acetate 

Relevant articles and documents

Indazole compounds and application thereof to preparation of IDO inhibitors

The invention discloses indazole compounds as shown in a formula (i) or (II) which is described in the specification, and a preparation method thereof, and application of the compounds as IDO inhibitors. The compounds provided by the invention can be used for preventing and/or treating a plurality of diseases, such as Alzheimer's disease, cataract, infections related to cellular immune activation,autoimmune diseases, AIDS, cancers, depression, the metabolic disorder of tryptophan or the like.

QUINAZOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS

Disclosed are a quinazolinone derivative, a preparation method therefor, a pharmaceutical composition, and applications. Provided are a compound represented by formula I, a pharmaceutically acceptable salt, a solvate, a crystal form, a eutectic crystal, a

MINERALOCORTICOID RECEPTOR ANTAGONISTS

Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophyl