1027403-46-8

Basic information

• Product Name: C₁₆H₁₅ClN₂O₅S
• CAS NO: 1027403-46-8
• Molecular Weight: 382.825
• Mol File: 1027403-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₅ClN₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₅ClN₂O₅S(1027403-46-8)
• EPA Substance Registry System: C₁₆H₁₅ClN₂O₅S(1027403-46-8)

Safety Data

• Hazardous Substances Data: 1027403-46-8(Hazardous Substances Data)

Upstream product

• 64900-65-8 2-chlorophenylsulfonyl isocyanate 
• 23284-84-6 N-phenylglycine methyl ester 

Relevant articles and documents

Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase

A series of 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives have been synthesized and evaluated for their ability to selectively inhibit human heart chymase. The structureactivity relationship studies on these compounds gave the following results. The 1-phenyl moiety participates in a hydrophobic interaction where an optimum size is required. At this position, 3,4-dimethylphenyl is the best moiety for inhibiting chymase and showed high selectivity compared with chymotrypsin and cathepsin G. A 3-phenylsulfonyl moiety substituted with hydrogen-bend acceptors such as nitrile and methoxycarbonyl enhances its activity. Molecular-modeling studies on the interaction of 3-[(4-chlorophenyl)sulfonyl]-1-(4-chlorophenyl)- imidazolidine-2,4-dione (29) with the active site of human heart chymase suggested that the 1-phenyl moiety interacts with the hydrophobic P1 pocket, the 3-phenylsulfonyl moiety resides in the S1-S2 subsites, and the 4- carbonyl of the imidazolidine ring and sulfonyl group interact with the oxyanion hole and the His-45 side chain of chymase, respectively. The complex model is consistent with the structure-activity relationships.