1027404-18-7

Basic information

• Product Name: 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride
• CAS NO: 1027404-18-7
• Molecular Weight: 336.177
• Mol File: 1027404-18-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(1027404-18-7)
• EPA Substance Registry System: 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(1027404-18-7)

Safety Data

• Hazardous Substances Data: 1027404-18-7(Hazardous Substances Data)

Upstream product

• 1027662-06-1 2-{[2-(2-methoxy-phenyl)-5-methyl-2H-pyrazol-3-ylamino]-methylene}-malonic acid diethyl ester 
• 1027168-24-6 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 91331-85-0 2-(2-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamine 
• 6971-45-5 2-methoxyphenylhydrazine hydrochloride 
• 851521-09-0 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Downstream Products

• 1026607-77-1 4-chloro-1-(2-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 

Relevant articles and documents

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.