1027458-34-9

Basic information

• Product Name: 2-[4-(4'-chloro-biphenyl-4-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
• Synonyms: 2-[4-(4'-chloro-biphenyl-4-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
• CAS NO: 1027458-34-9
• Molecular Weight: 581.092
• Mol File: 1027458-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(4'-chloro-biphenyl-4-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4'-chloro-biphenyl-4-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester(1027458-34-9)
• EPA Substance Registry System: 2-[4-(4'-chloro-biphenyl-4-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester(1027458-34-9)

Safety Data

• Hazardous Substances Data: 1027458-34-9(Hazardous Substances Data)

Upstream product

• 20443-74-7 4'-chlorobiphenyl-4-sulfonyl chloride 
• 234098-84-1 2-(2-oxopiperazin-1-ylmethyl)pyrrolo[3,2-c]pyridin-1-carboxylic acid tert-butyl ester 
• 234108-43-1 2-(4-benzyloxycarbonyl-2-oxopiperazin-1-ylmethyl)pyrrolo[3,2-c]pyridin-1-carboxylic acid tert-butyl ester 
• 234108-42-0 3-oxo-4-prop-2-ynylpiperazine-1-carboxylic acid benzyl ester 
• 211029-67-3 (3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester 
• 504-24-5 4-aminopyridine 

Relevant articles and documents

Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand

The discovery and SAR of ketopiperazino methylazaindole factor Xa inhibitors are described. Structure-activity data suggesting that this class of inhibitors does not bind in the canonical mode were confirmed by an X-ray crystal structure showing the neutral haloaromatic bound in the S1 subsite. The most potent azaindole, 33 (RPR209685), is selective against related serine proteases and attains higher levels of exposure upon oral dosing than comparable benzamidines and benzamidine isosteres. Compound 33 was efficacious in the canine AV model of thrombosis.