1027599-40-1

Basic information

• Product Name: 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-2-methyl-malonic acid diethyl ester
• CAS NO: 1027599-40-1
• Molecular Weight: 375.422
• Mol File: 1027599-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-2-methyl-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-2-methyl-malonic acid diethyl ester(1027599-40-1)
• EPA Substance Registry System: 2-(1-Benzyl-5-oxo-pyrrolidine-3-carbonyl)-2-methyl-malonic acid diethyl ester(1027599-40-1)

Safety Data

• Hazardous Substances Data: 1027599-40-1(Hazardous Substances Data)

Upstream product

• 5733-86-8 1-benzyl-5-oxopyrrolidine-3-carboxylic acid 
• 609-08-5 Diethyl methylmalonate 
• 114368-05-7 1-benzyl-2-pyrrolidinone-4-carboxylic acid chloride 

Downstream Products

• 107259-25-6 1-benzyl-3-(1-tert-butoxycarbonylaminopropyl)pyrrolidine 
• 107259-20-1 4-(1-aminopropyl)-1-benzyl-2-pyrrolidone 
• 107259-24-5 3-(1-Aminopropyl)-1-benzylpyrrolidine 
• 107259-21-2 1-benzyl-4-(1-hydroxyiminopropyl)-2-pyrrolidone 
• 163554-77-6 1-benzyl-4-propionylpyrrolidin-2-one 

Relevant articles and documents

Synthesis and structure-activity relationships of 7-[3-(1- aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials

A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1- pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).