10276-30-9

Basic information

• Product Name: 6-azauridine 5'-acetate
• Synonyms: 6-azauridine 5'-acetate
• CAS NO: 10276-30-9
• Molecular Weight: 287.229
• Mol File: 10276-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-azauridine 5'-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 6-azauridine 5'-acetate(10276-30-9)
• EPA Substance Registry System: 6-azauridine 5'-acetate(10276-30-9)

Safety Data

• Hazardous Substances Data: 10276-30-9(Hazardous Substances Data)

Upstream product

• 2169-64-4 2',3',5'-tri-O-acetyl-6-azauridine 

Relevant articles and documents

Hydrolysis of the prodrug, 2',3',5'-triacetyl-6-azauridine

Purpose. The purposes were to study the kinetics of hydrolysis of 2',3',5'-triacetyl-6-azauridine (1) in aqueous solution (μ = 0.5) and to identify the main intermediates and products of the reaction. Methods. A stability indicating isocratic LC assay was used to study the rate of degradation of 1. A gradient LC assay was used to study the time courses of the degradants. The products of hydrolysis were isolated by preparative liquid chromatography and identified by 1H-NMR and CI-MS. The pK(a) value was obtained by potentiometric titration. Results. At 36.8°C, the pH-rate profile of 1 in water was adequately described by a four-term rate equation. The intermediates were identified as the primary and secondary di-acetates, and the primary and secondary mono-acetates. The final product was 6-azauridine. Conclusions. A simplified kinetic scheme could be used to describe the concentration-time profiles of 1, the intermediates and the final product.