102762-46-9

Basic information

• Product Name: 4-Piperidinecarboxylic acid, 4-phenyl-1-(3-phenylpropyl)-, ethyl ester
• CAS NO: 102762-46-9
• Molecular Formula: C23H29NO2
• Molecular Weight: 351.489
• Mol File: 102762-46-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Piperidinecarboxylic acid, 4-phenyl-1-(3-phenylpropyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinecarboxylic acid, 4-phenyl-1-(3-phenylpropyl)-, ethyl ester(102762-46-9)
• EPA Substance Registry System: 4-Piperidinecarboxylic acid, 4-phenyl-1-(3-phenylpropyl)-, ethyl ester(102762-46-9)

Safety Data

• Hazardous Substances Data: 102762-46-9(Hazardous Substances Data)

Upstream product

• 116962-81-3 1-trans-cinnamyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 77-17-8 Normeperidine 
• 637-59-2 1-Bromo-3-phenylpropane 
• 101730-55-6 1-benzenesulfonyl-4-phenyl-piperidine-4-carboxylic acid 
• 101793-30-0 1-benzenesulfonyl-4-phenyl-piperidine-4-carbonitrile 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 1041870-85-2 4-phenyl-1-(3-phenyl-propyl)-piperidine-4-carbonitrile 
• 64-17-5 ethanol 
• 24465-45-0 ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride 

Relevant articles and documents

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate

Diphenoxylate, a well-known opioid agonist and anti-diarrhoeal agent, was recently found to block Kv1.3 potassium channels, which have been proposed as potential therapeutic targets for a range of autoimmune diseases. The molecular basis for this Kv1.3 blockade was assessed by the selective removal of functional groups from the structure of diphenoxylate as well as a number of other structural variations. Removal of the nitrile functional group and replacement of the C-4 piperidinyl substituents resulted in several compounds with submicromolar IC50 values.