102783-74-4

Basic information

• Product Name: 2'-Deoxyguanosine-5'-diphosphate trisodium salt
• Synonyms: 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE DISODIUM SALT;2'-DEOXYGUANOSINE 5'-DIPHOSPHATE SODIUM;2'-DEOXYGUANOSINE 5'-DIPHOSPHATE SODIUM SALT;dgdp;2''-DEOXYGUANOSINE-5''-DIPHOSPHATE, DISODIUM SALT (DGDP.NA2);2''-DEOXYGUANOSINE-5''-DIPHOSPHATE TRISODIUM SALT;2'-Deoxyguanosine 5'-diphosphoric acid;(2S)-2β,5β-Bis(hydroxymethyl)pyrrolidine-3β,4α-diol
• CAS NO: 102783-74-4
• Molecular Formula: C10H12N5Na3O10P2
• Molecular Weight: 493.15
• EINECS: 2017-001-1
• Mol File: 102783-74-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 919.1°Cat760mmHg
• Flash Point: 509.6°C
• Appearance: White/Powder
• Density: 2.49g/cm³
• Storage Temp.: −20°C
• Solubility: Aqueous Base (Slightly), Water (Slightly)
• Water Solubility: Soluble in water.
• Stability: Hygroscopic
• CAS DataBase Reference: 2'-Deoxyguanosine-5'-diphosphate trisodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Deoxyguanosine-5'-diphosphate trisodium salt(102783-74-4)
• EPA Substance Registry System: 2'-Deoxyguanosine-5'-diphosphate trisodium salt(102783-74-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 102783-74-4(Hazardous Substances Data)

Usage

Description

2'-Deoxyguanosine-5'-diphosphate trisodium salt, also known as dGDP, is a nucleotide consisting of a guanine base, deoxyribose, and two phosphate groups. It plays a crucial role in DNA biosynthesis and serves as a substrate for various enzymes and studies.

Uses

Used in Biochemical Research:
2'-Deoxyguanosine-5'-diphosphate trisodium salt is used as a substrate for dGDP (nucleoside diphosphate) kinase (2.7.4.6) or pyruvate kinase to produce dGTP, which supports DNA biosynthesis. This application is essential for understanding the fundamental processes of DNA replication and repair.
Used in Enzyme Kinetic Studies:
In the field of biochemistry, 2'-Deoxyguanosine-5'-diphosphate trisodium salt is used as a substrate to study the kinetics of glycoprotein (gp) 1.7 expressed by bacteriophage T7. This helps researchers understand the interactions between enzymes and their substrates, as well as the mechanisms of enzyme-catalyzed reactions.
Used in Molecular Biology:
2'-Deoxyguanosine-5'-diphosphate trisodium salt is also utilized in molecular biology applications, where it serves as a building block for the synthesis of DNA strands. This is particularly important in the development of new techniques and methods for genetic engineering and gene therapy.
Used in Pharmaceutical Industry:
The pharmaceutical industry employs 2'-Deoxyguanosine-5'-diphosphate trisodium salt in the development of drugs targeting DNA-related diseases, such as cancer and genetic disorders. By understanding the role of dGDP in DNA biosynthesis, researchers can design drugs that interfere with or enhance these processes, leading to potential therapeutic benefits.

Biochem/physiol Actions

2′-Deoxyguanosine 5′-diphosphate (dGDP) inhibits xanthine phosphoribosyl transferase (XPRT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT).