1027948-81-7

Basic information

• Product Name: C₂₄H₃₀N₂O₈S
• Synonyms: C₂₄H₃₀N₂O₈S
• CAS NO: 1027948-81-7
• Molecular Weight: 506.577
• Mol File: 1027948-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₀N₂O₈S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₀N₂O₈S(1027948-81-7)
• EPA Substance Registry System: C₂₄H₃₀N₂O₈S(1027948-81-7)

Safety Data

• Hazardous Substances Data: 1027948-81-7(Hazardous Substances Data)

Upstream product

• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 
• 30379-58-9 benzyl glycolate 
• 139059-69-1 <(S)(+)> methyl -phenylalaninate 

Downstream Products

• 249539-20-6 (4S)-5-acetyl-4-benzyl-2-(benzyloxycarbonyl)-1-methyl-3-oxo-1,2,5-thiadiazolidine 1,1-dioxide 
• 249539-09-1 (4S)-4-benzyl-2-(benzyloxycarbonyl)methyl-3-oxo-1,2,5-thiadiazolidine 1,1-dioxide 
• 249538-93-0 N-(benzyloxycarbonylmethyl)-N'-[(2'S)-2'-(methoxycarbonyl)phenethyl]sulfamide 

Relevant articles and documents

Sulfahydantoins as tripeptide constraints: Synthesis and structure of chiral substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides

A sulfahydantoin (3-oxo-1,2,5-thiadiazohdine 1,1-dioxides) motif is used as a new type of peptidic constraint to lock two consecutive amide nitrogens by a sulfonyl bridge. The 5membered heterocyclic motif was prepared starting from proteogenic and synthetic amino acids and chlorosulfonyl isocyanate. Constrained dipeptides were obtained under alkaline conditions (methoxide or tert-butoxide) by cyclization of symmetric and dissymmetric sulfamides. The absolute configuration of the chiral centers for the derivative L-Phe-D-Ala, a congener of the series, was established by X-ray diffraction crystallographic analysis. In addition, the chemo-, regio-, and stereoselectivities of the reactions were studied. In the acylated derivatives, the sulfahydantoin constraint induces a unique backbone conformation with coplanarity of two consecutive peptide bonds.