1027981-26-5

Basic information

• Product Name: 5(S)-[(tert-butyldiphenylsilyl)oxy]-12(R)-[(triethylsilyl)oxy]-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid methyl ester
• CAS NO: 1027981-26-5
• Molecular Weight: 703.166
• Mol File: 1027981-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5(S)-[(tert-butyldiphenylsilyl)oxy]-12(R)-[(triethylsilyl)oxy]-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5(S)-[(tert-butyldiphenylsilyl)oxy]-12(R)-[(triethylsilyl)oxy]-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid methyl ester(1027981-26-5)
• EPA Substance Registry System: 5(S)-[(tert-butyldiphenylsilyl)oxy]-12(R)-[(triethylsilyl)oxy]-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid methyl ester(1027981-26-5)

Safety Data

• Hazardous Substances Data: 1027981-26-5(Hazardous Substances Data)

Upstream product

• 245325-94-4 (R)-1,2-bis[(triethylsilyl)oxy]-4-decyne 
• 329896-85-7 (R)-1-[(triethylsilyl)oxy]-4-decyn-2-ol 
• 245326-02-7 (R)-2-[(triethylsilyl)oxy]-4-decynal 
• 90108-25-1 (E)-(S)-5-(tert-Butyl-diphenyl-silanyloxy)-10-(dimethoxy-phosphoryl)-dec-8-en-6-ynoic acid methyl ester 

Downstream Products

• 71160-24-2 Leukotriene B 

Relevant articles and documents

Total synthesis of 12(R)-HETE, 12(S)-HETE, 2H2-12(R)-HETE and LTB4 from racemic glycidol via hydrolytic kinetic resolution

The total synthesis of 12(R)-HETE, 12(S)-HETE (Samuelsson's HETE), [14,15-2H2]-12(R)-HETE and Leukotriene B4 from racemic glycidol is described. The key steps are the hydrolytic kinetic resolution of racemic TES-glycidol with salen-Co catalyst and the selective oxidation of primary silyl ethers, in the presence of secondary ones, under Swern conditions to give a short entry to both enantiomers of 12-HETE and LTB4.