1028-86-0

Basic information

• Product Name: N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE
• Synonyms: N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE;2-Chloro-3-(2-nitrobezamido)pyridine;N-(2-chloro-3-pyridyl)-o-nitrobenzamide;2-CHLORO-3-(2-NITROBENZAMIDO)PYRIDINE;N-(2-Chloro-3-pyridinyl)-2-nitrobenzamide
• CAS NO: 1028-86-0
• Molecular Formula: C₁₂H₈ClN₃O₃
• Molecular Weight: 277.66
• EINECS: 213-843-6
• Product Categories: pharmacetical
• Mol File: 1028-86-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 158.0-161.5 °C
• Boiling Point: 377.7 °C at 760 mmHg
• Flash Point: 182.2 °C
• Appearance: /
• Density: 1.498 g/cm³
• Vapor Pressure: 6.62E-06mmHg at 25°C
• Refractive Index: 1.684
• Storage Temp.: 2-8°C
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE(1028-86-0)
• EPA Substance Registry System: N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE(1028-86-0)

Safety Data

• Hazardous Substances Data: 1028-86-0(Hazardous Substances Data)

Usage

General Description

N-(2-chloropyridin-3-yl)-2-nitrobenzamide is a chemical compound with the molecular formula C12H8ClN3O3. It is a nitrobenzamide derivative with a chloropyridinyl group substituted in the 2-position and a nitro group in the 2-position of the benzamide. N-(2-CHLOROPYRIDIN-3-YL)-2-NITROBENZAMIDE is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It may also have potential applications as a pesticide or herbicide. N-(2-chloropyridin-3-yl)-2-nitrobenzamide should be handled and used with caution due to its potential toxicity and irritant properties.

InChI:InChI=1/C12H8ClN3O3/c13-11-9(5-3-7-14-11)15-12(17)8-4-1-2-6-10(8)16(18)19/h1-7H,(H,15,17)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 956-30-9 2-amino-N-(2-chloropyridin-3-yl)benzamide 
• 52333-96-7 2-(2-nitro-phenyl)oxazolo<5,4-b>pyridine 
• 826991-83-7 N-(2-chloro-pyridin-3-yl)-N-methyl-2-nitrobenzamide 
• 826991-84-8 2-amino-N-(2-chloro-pyridin-3-yl)-N-methyl-benzamide 
• 28797-48-0 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 
• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 
• 1152096-22-4 2-(2-nitrophenyl)thiazolo[5,4-b]pyridine 

Relevant articles and documents

2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms

A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.

An intestinal gastric pirenzepine hydrochloride is an important intermediate for simple synthesis process (by machine translation)

The invention discloses an intestinal gastric pirenzepine hydrochloride is an important intermediate for simple and convenient synthetic process, against the 5, 11 - dihydro - 11 - chloracetyl - 6 H - pyrido [2.3 - b] [1, 4] benzodiazepine - 6 - one synthetic, develops a piece of raw materials are simple and easy, simple operation of the synthesis process, in order to O-nitro benzoic acid and 2 - chloro - 3 - aminopyridine as a main raw material, five-step synthesis of the target compound, low cost, high yield, high purity, the final drug has far-reaching practical significance. (by machine translation)

SOLUBILIZED THIAZOLOPYRIDINES

Provided herein are novel sirtuin-modulating compounds Structural Formula (I): and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.