102804-43-3

Basic information

• Product Name: 2-Propenamide, N-(2-bromophenyl)-
• CAS NO: 102804-43-3
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.073
• Mol File: 102804-43-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-(2-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-(2-bromophenyl)-(102804-43-3)
• EPA Substance Registry System: 2-Propenamide, N-(2-bromophenyl)-(102804-43-3)

Safety Data

• Hazardous Substances Data: 102804-43-3(Hazardous Substances Data)

Usage

Physical appearance

White solid

Solubility

Sparingly soluble in water

Primary use

Intermediate in the synthesis of pharmaceuticals and organic compounds

Hazard classification

Classified as a hazardous substance

Health effects

Can cause irritation to skin, eyes, and respiratory system

Handling precautions

Handle with caution and follow proper safety protocols when working with it in a laboratory or industrial setting.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 814-68-6 acryloyl chloride 
• 615-36-1 2-bromoaniline 

Downstream Products

• 24438-17-3 1,3-dimethylindolin-2-one 
• 146499-15-2 N-Allyl-N-(2-bromo-phenyl)-acrylamide 
• 102804-47-7 N-(2-bromophenyl)-N-methyl-2-propenamide 
• 1504-06-9 3-methylindolin-2-one 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 

Relevant articles and documents

Disulfide Promoted C?P Bond Cleavage of Phosphoramide: “P” Surrogates to Synthesize Phosphonates and Phosphinates

A metal-free C?P bond cleavage reaction is described herein. Phosphoramides, a phosphine source, can react with alcohols to produce phosphonate and phosphinate derivatives in the presence of a disulfide. P?H2, P-alkyl, and P,P-dialkyl phosphoramides can be used as substrates to obtain the corresponding pentavalent phosphine products. (Figure presented.).

Cascade synthesis of spirooxindole δ-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates

A novel and highly efficient cascade synthesis of spirooxindole δ-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed.

Solid-phase synthesis of indol-2-ones by microwave-assisted radical cyclization

Solid-phase synthesis of indol-2-ones (2-oxindoles) by means of aryl radical cyclization of resin-bound N-(2-bromophenyl)acrylamides using Bu 3SnH is described. Among various solvents tested, DMF was found to be the best choice for the radical cyclization inducing a reagent concentration effect of the polymer support. The reaction proceeded smoothly under microwave irradiation to give the desired indol-2-ones within a very short reaction time in comparison to conventional thermal heating. In this reaction, various indol-2-ones were synthesized by using commercially available 2-bromoanilines and acryloyl chloride derivatives.