1028092-51-4

Basic information

• Product Name: 4-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzonitrile
• Synonyms: 4-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzonitrile
• CAS NO: 1028092-51-4
• Molecular Weight: 253.304
• Mol File: 1028092-51-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzonitrile(1028092-51-4)
• EPA Substance Registry System: 4-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzonitrile(1028092-51-4)

Safety Data

• Hazardous Substances Data: 1028092-51-4(Hazardous Substances Data)

Upstream product

• 903550-26-5 1-tetrahydropyran-1H-pyrazolylboronic ester 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 1028092-57-0 4-(2H-pyrazol-3-yl)benzonitrile hydrochloride 

Relevant articles and documents

A simple, modular method for the synthesis of 3,4,5-trisubstituted pyrazoles

(Chemical Equation Presented) A modular approach for the regiocontrolled preparation of pyrazoles bearing substituents on all three carbon atoms is described. Central to this method is the use of a switchable metal-directing group (MDG) to enable sequential direct lithiation of the 3- and 5-positions of the pyrazole ring. Pyrazole boronic esters obtained from these lithiated intermediates can undergo efficient Suzuki cross-coupling under the developed nonaqueous conditions, which minimize undesirable protolytic deboronation. Halogenation of the 4-position provides the means for substitution at the remaining carbon atom.