1028297-80-4

Basic information

• Product Name: 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
• Synonyms: 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS NO: 1028297-80-4
• Molecular Weight: 388.419
• Mol File: 1028297-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester(1028297-80-4)
• EPA Substance Registry System: 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester(1028297-80-4)

Safety Data

• Hazardous Substances Data: 1028297-80-4(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 31686-94-9 ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate 
• 17852-67-4 4-(methylsulfonyl)phenylhydrazine hydrochloride 

Downstream Products

• 1026299-78-4 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carbonyl chloride 
• 1027956-06-4 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid amide 
• 1026156-15-9 5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives

A series of novel 1,5-diarylpyrazole derivatives was synthesized and tested for anti-inflammatory and analgesic activities to develop anti- inflammatory agents with fewer side effects than existing nonsteroidal anti- inflammatory drugs. The structure-activity relationships in this series were extensively studied. Electron-withdrawing substituents such as CN and CF3 were optimal at the 3-position of the pyrazole ring. Replacement of these substituents with bulky ones gave less active compounds. The 4- (methylsulfonyl)phenyl group seemed to be the optimal group at the 5-position of the pyrazole ring. The most potent compound was 1-(4-fluorophenyl)-5-[4- (methylsulfonyl)phenyl]-pyrazole-3-carbonitrile (19a), with oral ED50 values of 0.030 and 0.47 mg/kg on adjuvant-induced arthritis and collagen- induced arthritis, respectively, and an ED30 value of 7.4 mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. Compound 19a also showed potent inducible cyclooxygenase (COX-2)-inhibitory activity (IC50=0.24μm) with no COX-1 inhibition even at 100μM.