10286-53-0

Basic information

• Product Name: 2-CYCLOHEXYLAMINO-BENZOIC ACID
• Synonyms: 2-CYCLOHEXYLAMINO-BENZOIC ACID
• CAS NO: 10286-53-0
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.27958
• Mol File: 10286-53-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 395°C at 760 mmHg
• Flash Point: 192.7°C
• Appearance: /
• Density: 1.192g/cm³
• Vapor Pressure: 6E-07mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CYCLOHEXYLAMINO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYCLOHEXYLAMINO-BENZOIC ACID(10286-53-0)
• EPA Substance Registry System: 2-CYCLOHEXYLAMINO-BENZOIC ACID(10286-53-0)

Safety Data

• Hazardous Substances Data: 10286-53-0(Hazardous Substances Data)

Usage

General Description

2-CYCLOHEXYLAMINO-BENZOIC ACID is a chemical compound with the molecular formula C13H17NO2. It is a derivative of benzoic acid and contains a cyclohexylamino group attached to the benzene ring. 2-CYCLOHEXYLAMINO-BENZOIC ACID is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. It is also known for its anti-inflammatory and analgesic properties, and it is sometimes used as an active ingredient in topical pain-relief creams and lotions. Additionally, 2-CYCLOHEXYLAMINO-BENZOIC ACID has been studied for its potential use in treating skin conditions such as acne. Overall, this chemical compound has a range of potential medical and industrial applications.

InChI:InChI=1/C13H17NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h4-5,8-10,14H,1-3,6-7H2,(H,15,16)

Upstream product

• 108-91-8 cyclohexylamine 
• 88-65-3 2-bromobenzoic-acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 108-94-1 cyclohexanone 
• 118-92-3 anthranilic acid 
• 88-67-5 2-Iodobenzoic acid 

Relevant articles and documents

PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis

Phenazines are redox-active bacterial secondary metabolites that participate in important biological processes such as the generation of toxic reactive oxygen species and the reduction of environmental iron. Their biosynthesis from chorismic acid depends

Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation

Ligand-free iron/copper cocatalyzed cross-coupling reactions of aryl halides with amines were carried out to provide the corresponding coupling products in good yields. It is worth noting that the method displays a broad substrate scope, and is convenient, rapid, low-cost and environmentally friendly.

Melatonin derivatives combat with inflammation-related cancer by targeting the Main Culprit STAT3

The combination between two well-studied bioactive compounds melatonin and salicylic acid with proper modifications unexpectedly creates a sharp pair of “scissors” cutting off the vicious connection between inflammation and cancer by targeting a key contributor Signal Transducers and Activators of Transcription 3 (STAT3) in the two pathological processes. A representative compound P-3 with IC50 values on each tested cell line ranging from 7.37 to 18.62 μM among the designed melatonin derivatives is equipped with the ability of curbing inflammation-promoting cancer by down-regulating the expression, activation and nuclear translocation of STAT3, breaking the feedforward loop of STAT3 activation by decreasing the expression of pro-tumorigenic cytokines, and inducing cell apoptosis through ROS triggered Cyto-c/Caspase-3 pathway. This study suggests that the melatonin derivative P-3 is likely to become a promising chemical structure for developing the novel anti-cancer agents taking effect through hindering the mutual-promoting processes between inflammation and cancer.

Sulfonato-Cu(salen) complex catalyzed N-arylation of aliphatic amines with aryl halides in water

A water-soluble sulfonato-Cu(salen) complex catalyzed procedure for the N-arylation of simple aliphatic amines, amino alcohols and amino acids in pure water have been developed. A variety of substituted aryl iodides, bromides and electron-deficient chlorides were found to be applicable, and 1,2-disubstituted benzimidazoles could be prepared easily by a cascade amination/condensation process in this catalytic system.