102869-99-8Relevant articles and documents
Activity of N-methyl-α- and -β-funaltrexamine at opioid receptors
Mohamed,Larson,Takemori,Portoghese
, p. 1551 - 1553 (1986)
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Crystals of morphinan derivative, manufacturing method thereof, and pharmaceutical composition using the same
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Paragraph 0037, (2014/09/03)
The present invention relates to a X-form crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride and the manufacturing method thereof, wherein the X-form crystal of the compound has char
Morphinan derivatives and pharmaceutical use thereof
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, (2008/06/13)
A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective κ-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.