102871-54-5Relevant articles and documents
Protease inhibitors (by machine translation)
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Paragraph 0023; 0030; 0031; 0032, (2018/09/28)
The invention relates to a Grp94 specific Hsp - 90 inhibitor, a protease inhibitor of the preparation method, to solve the existing problems on the preparation method of the blank defect, comprising the following processing steps: in the three flasks, is put into the water-free of dimethyl formamide, under the protection of nitrogen, adding 3, 5 - dichloro dithiol, completely dissolved after stirring, then slowly adding sodium hydride, stirring at room temperature the reaction 1 hours; then and then adding 8 - bromo - 9 - (3 - isopropylamino) propyl adenine, after adding gradually raising the temperature to 150 degrees, reflux reaction for 6 hours; after the reaction is complete cooling to room temperature, the reaction liquid is slowly added to the water, quenching the unreacted sodium hydride, methylene chloride/methanol mixed solution extraction, the organic phase is used for the saturated salt water and saturated ammonium chloride solution washing several times, and then after the saturated sodium bicarbonate multi-time extraction, for water-free magnesium sulfate drying, steaming and, for column chromatography column purification. (by machine translation)
