1029-38-5

Basic information

• Product Name: 1H-1,2,4-Triazole, 5-ethyl-1,3-diphenyl-
• CAS NO: 1029-38-5
• Molecular Formula: C16H15N3
• Molecular Weight: 249.315
• Mol File: 1029-38-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 5-ethyl-1,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 5-ethyl-1,3-diphenyl-(1029-38-5)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 5-ethyl-1,3-diphenyl-(1029-38-5)

Safety Data

• Hazardous Substances Data: 1029-38-5(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 15 carbon (C) atoms, 14 hydrogen (H) atoms, and 2 nitrogen (N) atoms.

Explanation

Triazole compounds are a class of heterocyclic organic compounds that contain three nitrogen atoms in a five-membered ring. This compound belongs to this family.

Explanation

The compound is heterocyclic because it contains atoms of different elements (carbon and nitrogen) in its ring structure.

Explanation

The triazole ring in the compound contains three nitrogen atoms.

Explanation

The compound has an ethyl group (-CH2CH3) attached to the triazole ring at the 5th position.

Explanation

The compound has two phenyl groups (C6H5) attached to the triazole ring at the 1st and 3rd positions.

Explanation

Studies have shown that this compound has potential biological activities, making it a subject of interest in medicinal chemistry and pharmacology.

Explanation

Due to its unique structure and potential biological activities, the compound is used as a building block in the synthesis of various pharmaceutical and agrochemical products.

Family

Triazole compounds

Heterocyclic

Yes

Nitrogen atoms

3

Presence of an ethyl group

Yes, at position 5

Presence of phenyl groups

Yes, at positions 1 and 3

Potential biological activities

Antimicrobial, antifungal, and anticancer properties

Application

Building block in the synthesis of pharmaceutical and agrochemical products

Upstream product

• 107-10-8 propylamine 
• 588-64-7 (E)-1-benzylidene-2-phenylhydrazine 
• 100-52-7 benzaldehyde 
• 100-63-0 phenylhydrazine 
• 586-96-9 Nitrosobenzene 
• 100-46-9 benzylamine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 107-12-0 propiononitrile 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 15601-98-6 propionaldehyde azine 
• 115591-23-6 1,3-diphenyl-5-vinyl-1H-1,2,4-triazole 

Relevant articles and documents

An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds

An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact

Formation of 1,2,4-Triazoles by Cation Radical Induced Oxidative Addition of Arylhydrazones of Benzaldehyde and Butyraldehyde to Nitriles

1,3,5-Trisubstituted 1,2,4-triazoles have been made in excellent yields by oxidative cycloaddition of arylhydrazones of benzaldehyde and butyraldehyde to aceto-, propio-, and acrylonitrile.Oxidation was achieved with the cation radicals thianthrenyl perchlorate (Th(radical)+ClO4-) and tris(2,4-dibromophenyl)aminium hexachloroantimonate (Ar3N(radical)+SbCl6-).The triazoles thus had a phenyl, p-nitrophenyl, or 2,4-dinitrophenyl group in the 1-position, either a phenyl or propyl group in the 3-position, and a methyl, ethyl, or vinyl group in the 5-position.The formation of 5-vinyltriazoles was confirmed by their hydrogenation to 5-ethyltriazoles, which were obtained also by cycloadditions to propionitrile.New triazoles (eight) were also synthesized by a known alternative route, but in lower yields.The fact that 5-vinyltriazoles were formed instead of 5-cyano-2-pyrazolines shows that cation radical induced cycloadditions do not go through the nitrilimines.Cycloadditions with N-phenylbenzohydrazonoyl chloride and acrylonitrile in the presence of aluminum chloride and of triethylamine were carried out for comparison with the corresponding cation radical reaction.

1,3-DIPOLAR CYCLOADDITIONS INDUCED BY CATION RADICALS. FORMATION OF 1,2,4-TRIAZOLES FROM OXIDATIVE ADDITION OF 1,4-DIPHENYLAZOMETHANE AND ARYL ALDEHYDE PHENYLHYDRAZONES TO NITRILES

Reaction of thianthrene cation radical perchlorate .(1+)*ClO4(1-)> with 1,4-diphenylazomethane (DPAM) in MeCN and EtCN led to the formation of 1,2,4-triazoles.Triazole formation is attributed to oxidative cycloaddition of benzaldehyde benzylhydrazone, the tautomer of DPAM, to the solvent nitriles.In confirmation, analogous cycloadditions were achieved by reaction of Th.(1+)*ClO4(1-) with some benzaldehyde phenylhydrazones in the same solvents.