1029438-23-0Relevant articles and documents
Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells
Bai, Lu,Wang, Xiaojie,Zhang, Kaifu,Tan, Xiaoyue,Zhang, Yuying,Xie, Wei
, p. 12996 - 12999 (2019)
No methodology has been built to distinguish intracellular SERS nanosensors from cell outer membrane bound-ones. Here we propose a turning off strategy by combining etchable SERS nanosensors with a non-permeable etchant. The SERS signals outside the living cells can be rapidly removed, leaving only the internalized nanosensors for imaging and thereby allowing accurate intracellular pH and H2O2 sensing.
5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS
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Page/Page column 107; 108, (2020/09/19)
The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.
A multi-state, allosterically-regulated molecular receptor with switchable selectivity
Mendez-Arroyo, Jose,Barroso-Flores, Joaquín,Lifschitz, Alejo M.,Sarjeant, Amy A.,Stern, Charlotte L.,Mirkin, Chad A.
supporting information, p. 10340 - 10348 (2014/08/05)
A biomimetic, ion-regulated molecular receptor was synthesized via the Weak-Link Approach (WLA). This structure features both a calix[4]arene moiety which serves as a molecular recognition unit and an activity regulator composed of hemilabile phosphine alkyl thioether ligands (P,S) chelated to a Pt(II) center. The host-guest properties of the ion-regulated receptor were found to be highly dependent upon the coordination of the Pt(II) center, which is controlled through the reversible coordination of small molecule effectors. The environment at the regulatory site dictates the charge and the structural conformation of the entire assembly resulting in three accessible binding configurations: one closed, inactive state and two open, active states. One of the active states, the semiopen state, recognizes a neutral guest molecule, while the other, the fully open state, recognizes a cationic guest molecule. Job plots and 1H NMR spectroscopy titrations were used to study the formation of these inclusion complexes, the receptor binding modes, and the receptor binding affinities (Ka) in solution. Single crystal X-ray diffraction studies provided insight into the solid-state structures of the receptor when complexed with each guest molecule. The dipole moments and electrostatic potential maps of the structures were generated via DFT calculations at the B97D/LANL2DZ level of theory. finally, we describe the reversible capture and release of guests by switching the receptor between the closed and semiopen configurations via elemental anion and small molecule effectors.
