1030513-24-6

Basic information

• Product Name: 4-benzothiazol-2-yl-benzoic acid ethyl ester
• Synonyms: 4-benzothiazol-2-yl-benzoic acid ethyl ester
• CAS NO: 1030513-24-6
• Molecular Weight: 283.351
• Mol File: 1030513-24-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-benzothiazol-2-yl-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzothiazol-2-yl-benzoic acid ethyl ester(1030513-24-6)
• EPA Substance Registry System: 4-benzothiazol-2-yl-benzoic acid ethyl ester(1030513-24-6)

Safety Data

• Hazardous Substances Data: 1030513-24-6(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 2182-78-7 4-(1,3-benzothiazol-2-yl)benzoic acid 
• 619-66-9 4-Carboxybenzaldehyde 
• 615-22-5 2-methylmercaptobenzothiazole 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 95-16-9 1,3-Benzothiazole 
• 105-07-7 4-cyanobenzaldehyde 
• 17930-02-8 2-(4'-cyanophenyl)benzothiazole 
• 64-17-5 ethanol 
• 1201-90-7 ethyl 4-chloromethylbenzoate 
• 137-07-5 2-amino-benzenethiol 
• 615-43-0 2-iodophenylamine 
• 88-73-3 2-Chloronitrobenzene 

Relevant articles and documents

Conversion of 2-(4-carboxyphenyl)-6-nitrobenzothiazole to 4-(6-amino-5-hydroxybenzothiazol-2-yl)benzoic acid by a recombinant E. coli strain

E. coli C43(DE3)pNbzAHabA, expressing nitroreductase and mutase enzymes, converts 2-(4-carboxyphenyl)-6-nitrobenzothiazole to 4-(6-amino-5- hydroxybenzothiazol-2-yl)benzoic acid. The Royal Society of Chemistry 2006.

Synthesis of some novel 4-benzothiazol-2-yl-benzoyl-1H-pyrazoles, and evaluation as antiangiogenic agents

Some 4-(1,3-benzothiazol-2-yl)-benzoyl-1H-pyrazole derivatives have been synthesized by reaction of o-aminothiophenol (1) with different electrophilic and nucleophilic reagents. All of the newly synthesized compounds were evaluated for cytotoxicity against breast cancer cell line MCF-7. Two of the compounds were more potent than tamoxifen and three were as potent as tamoxifen. These results were consistent with percentage inhibition of human VEGF compared with control untreated cells.

Elemental sulfur mediated cyclization via redox strategy: Synthesis of benzothiazoles from o-chloronitrobenzenes and benzyl chlorides

A novel metal-free synthesis of 2-substituted benzothiazoles from easily available o-chloronitrobenzenes and benzyl chlorides using elemental sulfur as traceless oxidizing agent has been developed. The protocol provides a simple, efficient, and atom-economic way to access to benzothiazoles in moderate to excellent yields. And the approach exhibited good functional group tolerance.

S8-Mediated Cyclization of 2-Aminophenols/thiophenols with Arylmethyl Chloride: Approach to Benzoxazoles and Benzothiazoles

A metal-free approach to benzazoles from arylmethyl chlorides and 2-mercaptan/2-hydroxyanilines using elemental sulfur as a traceless oxidizing agent has been developed. The reactions proceeded in good to excellent yields, exhibiting good functional groups tolerance and gram-scale ability. A key mechanistic investigation indicated that the key intermediate trisulfide 6, which was characterized by NMR, HRMS and crystal X-ray crystallography, was separated in the reaction prior to the formation of the product.