1031602-63-7
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Basic information
- Product Name: UNC3230
- Synonyms: UNC3230;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide
- CAS NO:1031602-63-7
- Molecular Formula: C17H20N4O2S
- Molecular Weight: 344.4313
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1031602-63-7.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: UNC3230(CAS DataBase Reference)
- NIST Chemistry Reference: UNC3230(1031602-63-7)
- EPA Substance Registry System: UNC3230(1031602-63-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1031602-63-7(Hazardous Substances Data)
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1031602-63-7 Usage
Description
UNC3230 is a small molecule inhibitor of Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C), a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). It has an IC50 of 41 nM and a Kd of 51 nM, and it does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.Uses
Used in Pain Management:UNC3230 is used as an antinociceptive agent for the management of chronic pain. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into the inflamed hindpaw.
Used in Neurobiology Research:
UNC3230 is used as a research tool for studying the role of PIP5K1C in pain sensitization and other signaling pathways. At 100 nM, it decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling, providing valuable insights into the mechanisms of pain regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 1031602-63-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,1,6,0 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.Calculate Digit Verification of CAS Registry Number 1031602-63:
(9*1)+(8*0)+(7*3)+(6*1)+(5*6)+(4*0)+(3*2)+(2*6)+(1*3)=87
87 % 10 = 7
So 1031602-63-7 is a valid CAS Registry Number.
1031602-63-7Upstream product
1031602-63-7Downstream Products
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UNC3230
