103205-23-8

Basic information

• Product Name: 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile
• Synonyms: 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile
• CAS NO: 103205-23-8
• Molecular Weight: 177.203
• Mol File: 103205-23-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile(103205-23-8)
• EPA Substance Registry System: 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile(103205-23-8)

Safety Data

• Hazardous Substances Data: 103205-23-8(Hazardous Substances Data)

Upstream product

• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 21667-60-7 3-methoxybenzoylacetonitrile 
• 591-31-1 3-methoxy-benzaldehyde 
• 75-05-8 acetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 914085-85-1 (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile 
• 255841-10-2 (S)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile 

Relevant articles and documents

Zinc-mediated addition of bromoacetonitrile to carbonyl compounds under solvent-free conditions

Zinc mediated addition reaction of bromoacetonitrile with aryl aldehydes and ketones produces β-hydroxynitriles under solvent-free conditions. The valuable feature of the methodology are solvent-free and catalyst-free conditions and short reaction times (5 min).

Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of β-hydroxy nitriles

Biocatalytic enantioselective hydrolysis of β-hydroxy nitriles to corresponding (S)-enriched β-hydroxy carboxylic acids has been achieved for the first time by an isolated nitrilase bII6402 from Bradyrhizobium japonicum USDA110. This offers a new "green" approach to optically pure β-hydroxy nitriles and β-hydroxy carboxylic acids. The observed remote stereorecognition is surprising because this nitrilase shows no enantioselectivity for the hydrolysis of α-hydroxy nitriles such as mandelonitrile.